Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padova, Via Giustiniani 5, 35128 Padova, Italy.
Expert Rev Neurother. 2011 Nov;11(11):1565-8. doi: 10.1586/ern.11.143.
The way we think of multiple sclerosis (MS) pathology has significantly changed over the last 10 years. Several studies clearly indicate that MS has to be considered a gray and white matter disease, where gray matter pathology probably plays a relevant role in determining physical and cognitive disability. The reviewed article presents new cross-sectional data on gray matter and white matter volumes across different MS phenotypes in a very large group of MS patients. In their study, the authors confirm an early and substantial deterioration of gray matter in MS and the evidence of a primary role of gray matter atrophy in the progression of clinical and cognitive disability. Another preliminary exciting step has therefore been taken toward the comprehension of the MS puzzle.
过去 10 年来，我们对多发性硬化症 (MS) 病理学的认识发生了重大变化。多项研究清楚地表明，MS 必须被视为一种灰质和白质疾病，其中灰质病理学可能在决定身体和认知残疾方面发挥相关作用。本文回顾了大量 MS 患者中不同 MS 表型的灰质和白质体积的新横断面数据。在他们的研究中，作者证实了 MS 患者的灰质很早就出现了实质性恶化，并且灰质萎缩在临床和认知残疾进展中起着主要作用。因此，我们朝着理解 MS 之谜迈出了令人兴奋的初步一步。
