Small Chanley M, Murray Deanna, Terrell Metrecia L, Marcus Michele
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Arch Environ Occup Health. 2011;66(4):201-8. doi: 10.1080/19338244.2010.539640.
The authors studied 194 women exposed to polybrominated biphenyls (PBB) in utero when their mothers consumed products accidentally contaminated in Michigan in 1973. Generalized estimating equations were used to examine the effect of in utero PBB exposure on adult pregnancy-related outcomes. Compared to those with the lowest exposure (≤1 ppb), those with mid-range (>1-3.16 ppb) and high (≥3.17 ppb) PBB exposure had increased odds of spontaneous abortion with wide confidence intervals (odds ratio [OR] = 2.75, 95% confidence interval [CI] = 0.64-11.79, OR = 4.08, 95% CI = 0.94-17.70; respectively; p for trend = .05). Exposure during infancy to PBB-contaminated breast milk further increased this risk. Time to pregnancy and infertility were not associated with in utero exposure to PBB. Future studies should examine the suggested relationship between spontaneous abortion and other brominated flame retardants.
作者对194名在子宫内接触多溴联苯（PBB）的女性进行了研究，这些女性的母亲在1973年食用了密歇根州意外受污染的产品。使用广义估计方程来研究子宫内接触多溴联苯对成人妊娠相关结局的影响。与暴露水平最低（≤1 ppb）的女性相比，中等暴露水平（>1 - 3.16 ppb）和高暴露水平（≥3.17 ppb）的女性自然流产几率增加，且置信区间较宽（优势比[OR]分别为2.75，95%置信区间[CI] = 0.64 - 11.79；OR = 4.08，95% CI = 0.94 - 17.70；趋势p值 = 0.05）。婴儿期接触受多溴联苯污染的母乳会进一步增加这种风险。怀孕时间和不孕与子宫内接触多溴联苯无关。未来的研究应考察自然流产与其他溴化阻燃剂之间的潜在关系。
