Talsness Chris E, Shakibaei Mehdi, Kuriyama Sergio N, Grande Simone Wichert, Sterner-Kock Anja, Schnitker Petra, de Souza Cristina, Grote Konstanze, Chahoud Ibrahim
Charité University Medical School Berlin, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystr. 5, 14195 Berlin, Germany.
Toxicol Lett. 2005 Jul 4;157(3):189-202. doi: 10.1016/j.toxlet.2005.02.001. Epub 2005 Mar 29.
Polybrominated diphenyl ethers (PBDEs), used as flame retardants in textiles, plastics and electrical appliances, have been shown to interfere with thyroid homeostasis. We evaluated the effects of environmentally relevant concentrations (low doses) of 2,2',4, 4',5-pentabromodiphenyl ether (PBDE-99) on the female reproductive system. A single dose of either 60 microg or 300 microg PBDE-99/kg body weight (BW) was administered on gestation day 6 to gravid Wistar rats. A reference control was treated with 6-n-propyl-2-thiouracil (PTU) on gestation days 7-21. Ultrastructural changes compatible with altered mitochondrial morphology were observed in the ovaries of the F1 offspring. No statistically significant changes in ovarian follicle counts were observed. Mating of the F1 females with untreated males revealed resorption rates in the PBDE groups greater than the limits considered normal for our controls. External and skeletal anomalies were detected in offspring (F2) from two different dams (F1) with early developmental exposure to 300 microg PBDE-99/kg BW. Exposure to PBDE-99 resulted in female reproductive tract changes in the F1 generation which were apparent at adulthood.
多溴二苯醚（PBDEs）被用作纺织品、塑料和电器中的阻燃剂，已被证明会干扰甲状腺稳态。我们评估了环境相关浓度（低剂量）的2,2',4,4',5-五溴二苯醚（PBDE-99）对雌性生殖系统的影响。在妊娠第6天，给妊娠的Wistar大鼠单次注射60微克或300微克PBDE-99/千克体重（BW）。在妊娠第7至21天，用6-正丙基-2-硫氧嘧啶（PTU）对参考对照组进行处理。在F1代后代的卵巢中观察到与线粒体形态改变相符的超微结构变化。未观察到卵巢卵泡计数有统计学上的显著变化。F1代雌性与未处理的雄性交配后发现，PBDE组的吸收发生率高于我们对照组认为正常的范围。在来自两只不同母鼠（F1）的后代（F2）中检测到外部和骨骼异常，这些母鼠在发育早期接触了300微克PBDE-99/千克体重。接触PBDE-99导致F1代雌性生殖道发生变化，这些变化在成年期明显可见。
