• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The spliceosome as an indicted conspirator in myeloid malignancies.剪接体作为髓系恶性肿瘤的罪魁祸首。
Cancer Cell. 2011 Oct 18;20(4):420-3. doi: 10.1016/j.ccr.2011.10.004.
2
The role of splicing factor mutations in the pathogenesis of the myelodysplastic syndromes.剪接因子突变在骨髓增生异常综合征发病机制中的作用。
Adv Biol Regul. 2014 Jan;54:153-61. doi: 10.1016/j.jbior.2013.09.005. Epub 2013 Sep 15.
3
Splicing factor mutant myelodysplastic syndromes: Recent advances.剪接因子突变性骨髓增生异常综合征：最新进展。
Adv Biol Regul. 2020 Jan;75:100655. doi: 10.1016/j.jbior.2019.100655. Epub 2019 Sep 19.
4
SF3B1 mutations in myelodysplastic syndromes: A potential therapeutic target for modulating the entire disease process.骨髓增生异常综合征中的SF3B1突变：调控整个疾病进程的潜在治疗靶点。
Front Oncol. 2023 Mar 17;13:1116438. doi: 10.3389/fonc.2023.1116438. eCollection 2023.
5
Impact of spliceosome mutation on outcomes of myelodysplastic syndrome and chronic myelomonocytic leukemia patients undergoing allogeneic hematopoietic cell transplantation.剪接体突变对接受异基因造血细胞移植的骨髓增生异常综合征和慢性粒单核细胞白血病患者结局的影响。
Leuk Res. 2024 Oct;145:107565. doi: 10.1016/j.leukres.2024.107565. Epub 2024 Aug 25.
6
The Biological and Clinical Consequences of RNA Splicing Factor U2AF1 Mutation in Myeloid Malignancies.髓系恶性肿瘤中RNA剪接因子U2AF1突变的生物学和临床后果
Cancers (Basel). 2022 Sep 10;14(18):4406. doi: 10.3390/cancers14184406.
7
Impact of Splicing Factor Mutations on Pre-mRNA Splicing in the Myelodysplastic Syndromes.剪接因子突变对骨髓增生异常综合征中前体mRNA剪接的影响
Curr Pharm Des. 2016;22(16):2333-44. doi: 10.2174/1381612822666160226132112.
8
Tumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations.在伴有剪接体突变的骨髓增生异常综合征中，肿瘤抑制性微小RNA表达下调。
Oncotarget. 2016 Mar 1;7(9):9951-63. doi: 10.18632/oncotarget.7127.
9
Mutations in the Spliceosomal Machinery Genes SRSF2, U2AF1, and ZRSR2 and Response to Decitabine in Myelodysplastic Syndrome.剪接体机制基因SRSF2、U2AF1和ZRSR2的突变与骨髓增生异常综合征对地西他滨的反应
Anticancer Res. 2015 May;35(5):3081-9.
10
Therapeutic approaches targeting splicing factor mutations in myelodysplastic syndromes and acute myeloid leukemia.针对骨髓增生异常综合征和急性髓系白血病中剪接因子突变的治疗方法。
Curr Opin Hematol. 2021 Mar 1;28(2):73-79. doi: 10.1097/MOH.0000000000000632.

引用本文的文献

1
Research Progress on the Relationship Between PRPF8 and Cancer.PRPF8与癌症关系的研究进展
Curr Issues Mol Biol. 2025 Feb 26;47(3):150. doi: 10.3390/cimb47030150.
2
Tyrosine kinase inhibitors induce alternative spliced BCR-ABL variant via inhibition of RNA polymerase II on genomic BCR-ABL.酪氨酸激酶抑制剂通过抑制基因组 BCR-ABL 上的 RNA 聚合酶 II 诱导 BCR-ABL 变体的剪接。
Cancer Sci. 2020 Jul;111(7):2361-2373. doi: 10.1111/cas.14424. Epub 2020 Jun 14.
3
Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells.基于蛋白质组学的证据表明 ESRP1 在人结直肠癌细胞中发挥致癌作用。
Int J Mol Sci. 2020 Jan 16;21(2):575. doi: 10.3390/ijms21020575.
4
Signaling Pathways Driving Aberrant Splicing in Cancer Cells.驱动癌细胞异常剪接的信号通路。
Genes (Basel). 2017 Dec 29;9(1):9. doi: 10.3390/genes9010009.
5
Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1.剪接因子SF3B1 K700E突变体通过转录因子TAL1的异常可变剪接失调红细胞分化。
PLoS One. 2017 May 18;12(5):e0175523. doi: 10.1371/journal.pone.0175523. eCollection 2017.
6
SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing.SF3B1/Hsh155热基序突变影响与剪接体ATP酶Prp5的相互作用，导致前体mRNA剪接中分支位点选择性改变。
Genes Dev. 2016 Dec 15;30(24):2710-2723. doi: 10.1101/gad.291872.116.
7
Resistance to imatinib in patients with chronic myelogenous leukemia and the splice variant BCR-ABL1(35INS).慢性粒细胞白血病患者对伊马替尼的耐药性与剪接变体BCR-ABL1(35INS)
Leuk Res. 2016 Oct;49:108-12. doi: 10.1016/j.leukres.2016.08.006. Epub 2016 Aug 12.
8
Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes.SF3B1 突变型骨髓增生异常综合征中铁转运蛋白ABCB7及其他关键靶基因的隐匿性剪接事件
Leukemia. 2016 Dec;30(12):2322-2331. doi: 10.1038/leu.2016.149. Epub 2016 May 23.
9
The prognostic impact of mutations in spliceosomal genes for myelodysplastic syndrome patients without ring sideroblasts.剪接体基因突变对无环形铁粒幼细胞的骨髓增生异常综合征患者的预后影响
BMC Cancer. 2015 Jun 27;15:484. doi: 10.1186/s12885-015-1493-5.
10
Prp40 pre-mRNA processing factor 40 homolog B (PRPF40B) associates with SF1 and U2AF65 and modulates alternative pre-mRNA splicing in vivo.Prp40前体mRNA加工因子40同源物B（PRPF40B）与SF1和U2AF65结合，并在体内调节前体mRNA的可变剪接。
RNA. 2015 Mar;21(3):438-57. doi: 10.1261/rna.047258.114. Epub 2015 Jan 20.

本文引用的文献

1
Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts.环形铁幼粒细胞性难治性贫血伴多系发育异常中的体细胞 SF3B1 突变。
N Engl J Med. 2011 Oct 13;365(15):1384-95. doi: 10.1056/NEJMoa1103283. Epub 2011 Sep 26.
2
Frequent pathway mutations of splicing machinery in myelodysplasia.骨髓增生异常综合征中剪接机制的频繁通路突变。
Nature. 2011 Sep 11;478(7367):64-9. doi: 10.1038/nature10496.
3
A comprehensive catalogue of somatic mutations from a human cancer genome.一个人类癌症基因组中体细胞突变的综合目录。
Nature. 2010 Jan 14;463(7278):191-6. doi: 10.1038/nature08658. Epub 2009 Dec 16.
4
Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation.糖原合酶激酶3β剪接异常促成白血病干细胞的产生。
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3925-9. doi: 10.1073/pnas.0900189106. Epub 2009 Feb 23.
5
Local dystrophin restoration with antisense oligonucleotide PRO051.使用反义寡核苷酸PRO051进行局部肌营养不良蛋白恢复
N Engl J Med. 2007 Dec 27;357(26):2677-86. doi: 10.1056/NEJMoa073108.
6
The genomic landscapes of human breast and colorectal cancers.人类乳腺癌和结直肠癌的基因组图谱。
Science. 2007 Nov 16;318(5853):1108-13. doi: 10.1126/science.1145720. Epub 2007 Oct 11.
7
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.剪接抑制素A作用于剪接因子3b（SF3b），并抑制前体信使核糖核酸（pre-mRNA）的剪接和核滞留。
Nat Chem Biol. 2007 Sep;3(9):576-83. doi: 10.1038/nchembio.2007.18. Epub 2007 Jul 22.
8
Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1.哺乳动物中多梳蛋白介导的Hox基因抑制作用需要必需的剪接体蛋白Sf3b1。
Genes Dev. 2005 Mar 1;19(5):536-41. doi: 10.1101/gad.1284605.
9
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle.ASF/SF2调控的CaMKIIdelta可变剪接在时间上对心肌中的兴奋-收缩偶联进行重新编程。
Cell. 2005 Jan 14;120(1):59-72. doi: 10.1016/j.cell.2004.11.036.
10
Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart.心脏中SC35的组织特异性消融导致的扩张型心肌病。
EMBO J. 2004 Feb 25;23(4):885-96. doi: 10.1038/sj.emboj.7600054. Epub 2004 Feb 12.

剪接体作为髓系恶性肿瘤的罪魁祸首。

The spliceosome as an indicted conspirator in myeloid malignancies.

机构信息

Human Oncology and Pathogenesis Program, Leukemia Service, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA.

出版信息

Cancer Cell. 2011 Oct 18;20(4):420-3. doi: 10.1016/j.ccr.2011.10.004.

DOI:10.1016/j.ccr.2011.10.004
PMID:22014568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3218079/
Abstract

Reports of whole-exome sequencing in myelodysplastic syndrome (MDS) patients by Yoshida et al. and Papaemmanuil et al. suggest spliceosome mutations have clinical relevance. Identifying the impact of these mutations on MDS pathogenesis holds promise for therapeutic modulation of mRNA splicing.

摘要

Yoshida 等人和 Papaemmanuil 等人报道的骨髓增生异常综合征 (MDS) 患者全外显子测序报告表明剪接体突变具有临床相关性。确定这些突变对 MDS 发病机制的影响有望为调节 mRNA 剪接的治疗提供帮助。