Department of Radiation Oncology, Vanderbilt University, Nashville, TN 37232-2279, USA.
Cancer Cell. 2011 Oct 18;20(4):423-5. doi: 10.1016/j.ccr.2011.10.006.
The EGFR-directed antibody cetuximab has proven, albeit modest, clinical benefit as monotherapy in head and neck and colorectal cancers. In a recent study, Yonesaka et al. uncovered a new mechanism of cetuximab resistance mediated by increased ERBB2 signaling via amplification of ERBB2 or increased levels of the ERBB3/ERBB4 ligand heregulin.
表皮生长因子受体(EGFR)导向抗体西妥昔单抗已被证明,尽管作用有限,但在头颈部和结直肠癌的单药治疗中具有临床益处。在最近的一项研究中,Yonesaka 等人发现了一种新的西妥昔单抗耐药机制,该机制通过 ERBB2 或 ERBB3/ERBB4 配体神经调节蛋白的扩增导致 ERBB2 信号的增加而介导。