Department of Neurology, Pusan National University, Yangsan Hospital, Research Institute for Convergence of Biomedical Science and Technology, Yangsan, Republic of Korea.
J Neurol Sci. 2012 Feb 15;313(1-2):54-6. doi: 10.1016/j.jns.2011.09.031. Epub 2011 Oct 20.
Signal abnormalities of cortical gray matter, compared with the deep nuclear structures, have received less attention in Wilson's disease (WD). They nearly always accompanied white matter signal change, and commonly are associated with epilepsy and psychiatric features. We report herein two cases diagnosed as WD who, in addition to characteristic deep nuclear lesions on MR imaging, had widespread cerebral cortical paramagnetic signals dramatically detected by susceptibility-weighted imaging. T2-weighted MR images did not show any cortico-subcortical hyperintense lesions. To our knowledge, these findings have not been described before and may help to further characterize the disease.
脑皮质灰质的信号异常与深部核结构相比，在威尔逊病（WD）中受到的关注较少。它们几乎总是伴随着脑白质信号改变，通常与癫痫和精神症状有关。我们在此报告 2 例 WD 患者，除了磁共振成像上具有特征性的深部核病变外，还通过磁敏感加权成像显著检测到广泛的大脑皮质顺磁性信号。T2 加权磁共振图像未显示任何皮质下高信号病变。据我们所知，这些发现以前尚未描述过，可能有助于进一步描述该疾病。
