肝豆状核变性患者脑部的磁敏感加权成像表现
Susceptibility-Weighted Imaging Manifestations in the Brain of Wilson's Disease Patients.
作者信息
Yang Jinjing, Li Xiaohu, Yang Renmin, Yu Xuen, Yu Changliang, Qian Yinfeng, Yu Yongqiang
机构信息
Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Department of Neurology, The Hospital Affiliated of Anhui College of TCM, Hefei, China.
出版信息
PLoS One. 2015 Apr 27;10(4):e0125100. doi: 10.1371/journal.pone.0125100. eCollection 2015.
PURPOSE
It is well known that patients with Wilson's disease (WD) suffer copper metabolism disorder. However, recent studies point to an additional iron metabolism disorder in WD patients. The purpose of our study was to examine susceptibility-weighted imaging (SWI) manifestations of WD in the brains of WD patients.
METHODS
A total of 33 patients with WD and 18 normal controls underwent conventional MRI (Magnetic resonance imaging) and SWI. The phase values were measured on SWI-filtered phase images of the bilateral head of the caudate nuclei, globus pallidus, putamen, thalamus, substantia nigra, and red nucleus. Student's t-tests were used to compare the phase values between WD groups and normal controls.
RESULTS
The mean phase values for the bilateral head of the caudate nuclei, globus pallidus, putamen, thalamus, substantia nigra, and red nucleus were significantly lower than those in the control group (P < 0.001), and bilateral putamen was most strongly affected.
CONCLUSIONS
There is paramagnetic mineralization deposition in brain gray nuclei of WD patients and SWI is an effective method to evaluate these structures.
目的
众所周知，威尔逊病（WD）患者存在铜代谢紊乱。然而，最近的研究指出WD患者还存在铁代谢紊乱。我们研究的目的是检查WD患者大脑中WD的磁敏感加权成像（SWI）表现。
方法
共33例WD患者和18名正常对照者接受了常规磁共振成像（MRI）和SWI检查。在双侧尾状核头部、苍白球、壳核、丘脑、黑质和红核的SWI滤波相位图像上测量相位值。采用学生t检验比较WD组和正常对照组之间的相位值。
结果
双侧尾状核头部、苍白球、壳核、丘脑、黑质和红核的平均相位值显著低于对照组（P < 0.001），双侧壳核受影响最严重。
结论
WD患者脑灰质核团存在顺磁性矿物质沉积，SWI是评估这些结构的有效方法。
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