评价大戟根皮对艾氏腹水癌的抗肿瘤活性。
Evaluation of antitumour activity of Calotropis gigantea L. root bark against Ehrlich ascites carcinoma in Swiss albino mice.
机构信息
Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205, Bangladesh.
出版信息
Asian Pac J Trop Med. 2011 Oct;4(10):786-90. doi: 10.1016/S1995-7645(11)60194-6.
OBJECTIVE
To investigate experimentally the possible antitumor effect of methanol extract (ME) of Calotropis gigantea L. (C. gigantean) root bark and its petroleum ether (PEF) and chloroform (CF) soluble fractions against Ehrlich ascites carcinoma (EAC) in Swiss albino mice.
METHODS
The effects of ME (10 and 20 mg/kg), PEF (40 and 80 mg/kg) and CF (20 and 40 mg/kg) on the growth of EAC and life span of EAC bearing mice were studied. Hematological profile and biochemical parameters (SALP, SGPT and SGOT) were also estimated.
RESULTS
Results of in vivo study showed a significant decrease in viable tumor cell count and a significant increase of life span in the ME and CF treated group compared to untreated one. The life span of ME and CF treated animals was significantly (P<0.05) increased by 43.90% (20 mg ME/kg) and 57.07% (40 mg CF/kg). ME and CF brought back the hematological parameter more or less normal level. ME and CF also restored the altered levels of serum alkaline phosphatase (SALP) and serum glutamate oxaloacetate transaminase (SGOT).
CONCLUSIONS
Methanol extract (ME) of C. gigantea root bark and its chloroform soluble fraction (CF) possesses significant antitumor activity.
目的
实验研究大角豆根甲醇提取物（ME）及其石油醚（PEF）和氯仿（CF）可溶性部分对瑞士白化病小鼠艾氏腹水癌（EAC）的可能抗肿瘤作用。
方法
研究 ME（10 和 20mg/kg）、PEF（40 和 80mg/kg）和 CF（20 和 40mg/kg）对 EAC 生长和 EAC 荷瘤小鼠寿命的影响。还评估了血液学参数和生化参数（SALP、SGPT 和 SGOT）。
结果
体内研究结果表明，与未处理组相比，ME 和 CF 处理组的活肿瘤细胞计数显著减少，寿命显著延长。ME 和 CF 处理动物的寿命分别显著（P<0.05）提高了 43.90%（20mg ME/kg）和 57.07%（40mg CF/kg）。ME 和 CF 使血液学参数或多或少恢复正常水平。ME 和 CF 还恢复了血清碱性磷酸酶（SALP）和血清谷氨酸草酰乙酸转氨酶（SGOT）的改变水平。
结论
大角豆根甲醇提取物（ME）及其氯仿可溶性部分（CF）具有显著的抗肿瘤活性。
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