Saunders Natasha Ruth, Hellmann Jonathan, Farine Dan
Department of Paediatrics, Hospital for Sick Children and Faculty of Medicine, University of Toronto, Toronto ON.
Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto ON.
J Obstet Gynaecol Can. 2011 Oct;33(10):1038-1043. doi: 10.1016/S1701-2163(16)35053-8.
Assisted reproductive technologies have been widely used over the past 30 years, and 1% to 4% of births worldwide are products of these technologies. However, adverse health outcomes related to assisted reproductive technologies, including cerebral palsy, have been reported. We extracted and reviewed all relevant studies cited by Medline from 1996 to 2010 evaluating the role of assisted reproductive technologies as a causative factor for cerebral palsy and poor long-term neurologic outcome. The research suggests that multiple pregnancy, preterm delivery, and babies small for gestational age are factors in the development of cerebral palsy. The vanishing embryo syndrome may also play a role. We review the evidence for these potentially causative factors, as well as their implications for embryo transfer policies.
在过去30年里，辅助生殖技术得到了广泛应用，全球1%至4%的新生儿是这些技术的产物。然而，已有报道称辅助生殖技术会带来不良健康后果，包括脑瘫。我们检索并回顾了1996年至2010年期间Medline引用的所有相关研究，这些研究评估了辅助生殖技术作为脑瘫和长期神经功能不良致病因素的作用。研究表明，多胎妊娠、早产和小于胎龄儿是脑瘫发展的因素。消失胚胎综合征也可能起作用。我们回顾了这些潜在致病因素的证据，以及它们对胚胎移植政策的影响。
