Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA.
Clin Dermatol. 2011 Nov-Dec;29(6):644-51. doi: 10.1016/j.clindermatol.2011.08.027.
Ultraviolet (UV) radiation is an established carcinogen that causes skin cancers and other cutaneous photodamage. Vitamin D is produced in the skin after UV exposure and may also be obtained from dietary and supplemental sources. The effect of recommendations for UV protection, as well as for very large vitamin D supplements, and possible adverse effects of both are explored. Current evidence supports the conclusion that protection from UV radiation reduces the incidence of skin cancers and photodamage, but generally does not compromise vitamin D status or lead to iatrogenic disease. Conversely, risks of maintaining very high vitamin D levels have not been adequately studied. Vitamin D obtained from diet and supplements is functionally identical to that produced after UV exposure, and is a more reliable and quantifiable source of the vitamin.
紫外线（UV）辐射是一种已确定的致癌物质，会导致皮肤癌和其他皮肤光损伤。维生素 D 在皮肤暴露于 UV 后产生，也可以从饮食和补充剂中获得。本文探讨了推荐使用 UV 防护措施以及非常大剂量的维生素 D 补充剂的效果，以及这两者可能产生的不良反应。目前的证据支持这样的结论，即防止紫外线辐射可以降低皮肤癌和光损伤的发生率，但通常不会影响维生素 D 状态或导致医源性疾病。相反，维持非常高的维生素 D 水平的风险尚未得到充分研究。从饮食和补充剂中获得的维生素 D 在功能上与 UV 暴露后产生的维生素 D 相同，并且是更可靠和可量化的维生素来源。
