Kim Min-Jeong, Kim Sunmie, Kim Jin Ju, Han Kyung Hee
Department of Obstetrics and Gynecology, Division of Gynecology Oncology, CHA Hospital Ilsan Medical Center, Goyang-si, Gyonggi-do, Republic of Korea.
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Hospital Healthcare System Gangnam Center, 39FL., Gangnam Finance Center, 152 Teheran-ro, Gangnam-gu, Seoul, 06236, South Korea.
J Bone Miner Metab. 2025 Mar;43(2):86-95. doi: 10.1007/s00774-024-01556-w. Epub 2024 Sep 30.
The association between serum vitamin D levels and bone mineral density (BMD) varies by race and gender. This study aimed to evaluate this relationship between serum vitamin D levels and BMD, and changes of BMD over time in Korean women.
We analyzed data from 586 generally healthy Korean women aged 29-79 who underwent health check-ups at Seoul National University Gangnam Center between 2010 and 2011 (baseline measurement) and 2015-2016 (follow-up). Dual energy X-ray absorptiometry (DEXA) and serum 25-hydroxyvitamin D (25OH-D) level measurements were conducted. We assessed the association between serum 25OH-D levels and BMD, as well as changes in BMD over time.
The mean age of participants was 51.3 ± 7.9 years, with a mean follow-up interval of 4.6 ± 0.7 years, and mean serum 25OH-D level of 20.6 ± 8.5 ng/ml. Baseline serum 25OH-D levels did not correlate with BMD values at the lumbar spine, femoral neck, or total femur, nor with changes in BMD over time. A significant negative association was found between perimenopausal status and BMD changes at all sites, and between premenopausal status and lumbar bone mass, compared to postmenopausal status in the 25OH-D < 20 ng/ml group. This association was not observed in women with higher serum 25OH-D levels.
Serum 25OH-D levels did not correlate with BMD levels or changes in BMD overall. However, in late reproductive-aged and perimenopausal women with serum 25OH-D insufficiency, there was a significant association with accelerated bone loss.
血清维生素D水平与骨密度（BMD）之间的关联因种族和性别而异。本研究旨在评估韩国女性血清维生素D水平与骨密度之间的这种关系，以及骨密度随时间的变化。
我们分析了586名年龄在29 - 79岁之间、总体健康的韩国女性的数据，这些女性于2010年至2011年（基线测量）以及2015年至2016年（随访）在首尔国立大学江南中心接受了健康检查。进行了双能X线吸收法（DEXA）和血清25 - 羟基维生素D（25OH - D）水平测量。我们评估了血清25OH - D水平与骨密度之间的关联，以及骨密度随时间的变化。
参与者的平均年龄为51.3±7.9岁，平均随访间隔为4.6±0.7年，平均血清25OH - D水平为20.6±8.5 ng/ml。基线血清25OH - D水平与腰椎、股骨颈或全股骨的骨密度值均无相关性，也与骨密度随时间的变化无关。在25OH - D＜20 ng/ml组中，与绝经后状态相比，围绝经期状态与所有部位的骨密度变化之间以及绝经前状态与腰椎骨量之间存在显著负相关。在血清25OH - D水平较高的女性中未观察到这种关联。
血清25OH - D水平与骨密度水平或总体骨密度变化无关。然而，在血清25OH - D不足的晚育年龄和围绝经期女性中，与骨量加速流失存在显著关联。
