Department of Obstetrics and Gynecology, Oulu University Hospital, PO Box 5000, FIN-90014 Oulu, Finland.
Placenta. 2011 Dec;32(12):999-1003. doi: 10.1016/j.placenta.2011.10.005. Epub 2011 Oct 19.
Pregnancy Associated Protein A (PAPP-A), A Disintegrin and Metalloproteinase 12 (ADAM12) and Placental Protein 13 (PP13) are secreted from the placental trophoblastic tissue and are involved in normal implantation and placental development. The aim of the study was to assess the connection between the secretion of these proteins and the growth of the gestational sac and the placenta.
In an observational longitudinal study at Oulu University Hospital, women with naturally conceived pregnancies were followed-up weekly to pregnancy week 11.
PAPP-A, ADAM12 and PP13 serum concentrations and their correlation with the volumes of the gestational sac and the placenta were assessed using three-dimensional ultrasonography.
The study group consisted of 41 women. The PAPP-A, ADAM12 and PP13 serum concentrations increased continuously from pregnancy week 4 to week 11 and correlated closely with each other. The serum concentrations of PAPP-A, ADAM12 and PP13 also correlated with the volumes of the gestational sac and the placenta up to pregnancy week 8.
The secretion of PAPP-A, ADAM12 and PP13 is closely related to the size of the placenta in the beginning of pregnancy. After 8 weeks of pregnancy, which is the time for luteoplacental shift, the correlation disappears, possibly reflecting the morphologic transformation in the placenta.
胎盘蛋白 A（PAPP-A）、解整合素金属蛋白酶 12（ADAM12）和胎盘蛋白 13（PP13）均由胎盘滋养层组织分泌，参与正常着床和胎盘发育。本研究旨在评估这些蛋白质的分泌与孕囊和胎盘生长之间的关系。
在奥卢大学医院进行的一项观察性纵向研究中，对自然受孕的女性进行每周随访至妊娠第 11 周。
采用三维超声评估 PAPP-A、ADAM12 和 PP13 血清浓度及其与孕囊和胎盘体积的相关性。
研究组包括 41 名女性。PAPP-A、ADAM12 和 PP13 的血清浓度从妊娠第 4 周到第 11 周持续增加，彼此之间密切相关。PAPP-A、ADAM12 和 PP13 的血清浓度与孕囊和胎盘体积在妊娠第 8 周前也相关。
PAPP-A、ADAM12 和 PP13 的分泌与妊娠早期胎盘的大小密切相关。妊娠 8 周后，即黄体胎盘转移期，相关性消失，可能反映了胎盘的形态学变化。
