Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands.
Spine J. 2011 Nov;11(11):1058-67. doi: 10.1016/j.spinee.2011.09.014. Epub 2011 Oct 20.
Diffuse idiopathic skeletal hyperostosis (DISH) is a common but underdiagnosed condition relating to ossification of spinal ligaments that can cause compression of the esophagus and trachea. According to case reports, dysphagia or airway obstruction resulting from DISH is a rare occurrence.
This study was intended to identify all published cases of dysphagia and/or airway obstruction resulting from DISH to increase the epidemiologic/clinical knowledge of these related conditions.
A systematic review of the literature was performed.
The articles resulting from the systematic PubMed/EMBASE search of the literature were closely read, and predefined parameters were scored.
The search yielded a total of 118 articles (95 case reports and 23 case series) describing 204 patients with dysphagia and/or airway obstruction resulting from DISH. The number of cases demonstrated a steady increase from 1980 to 2009. This might be a real effect not ascribable to publication bias or expansion of the medical literature alone.
Diffuse idiopathic skeletal hyperostosis as a cause of dysphagia and/or airway obstruction may be an increasing and underappreciated phenomenon. Diffuse idiopathic skeletal hyperostosis should be included in the differential diagnosis of dysphagia and airway obstruction.
弥漫性特发性骨肥厚（DISH）是一种常见但诊断不足的疾病，与脊柱韧带的骨化有关，可导致食管和气管受压。根据病例报告，DISH 引起的吞咽困难或气道阻塞较为罕见。
本研究旨在确定所有因 DISH 引起的吞咽困难和/或气道阻塞的病例报告，以增加对这些相关疾病的流行病学/临床认识。
系统文献回顾。
对文献进行了系统的 PubMed/EMBASE 搜索，仔细阅读了检索到的文章，并对预设参数进行了评分。
搜索共产生了 118 篇文章（95 篇病例报告和 23 篇病例系列），描述了 204 例因 DISH 引起的吞咽困难和/或气道阻塞的患者。从 1980 年到 2009 年，病例数量呈稳步增加趋势。这可能是一个真实的效应，不能归因于发表偏倚或仅归因于医学文献的扩展。
弥漫性特发性骨肥厚作为吞咽困难和/或气道阻塞的原因可能是一个日益增加但未被充分认识的现象。弥漫性特发性骨肥厚应纳入吞咽困难和气道阻塞的鉴别诊断中。
