提高谷胱甘肽水平作为阿尔茨海默病的一种治疗策略。
Elevation of glutathione as a therapeutic strategy in Alzheimer disease.
作者信息
Pocernich Chava B, Butterfield D Allan
机构信息
Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.
出版信息
Biochim Biophys Acta. 2012 May;1822(5):625-30. doi: 10.1016/j.bbadis.2011.10.003. Epub 2011 Oct 12.
Abstract
Oxidative stress has been associated with the onset and progression of mild cognitive impairment (MCI) and Alzheimer disease (AD). AD and MCI brain and plasma display extensive oxidative stress as indexed by protein oxidation, lipid peroxidation, free radical formation, DNA oxidation, and decreased antioxidants. The most abundant endogenous antioxidant, glutathione, plays a significant role in combating oxidative stress. The ratio of oxidized to reduced glutathione is utilized as a measure of intensity of oxidative stress. Antioxidants have long been considered as an approach to slow down AD progression. In this review, we focus on the elevation on glutathione through N-acetyl-cysteine (NAC) and γ-glutamylcysteine ethyl ester (GCEE) as a potential therapeutic approach for Alzheimer disease. This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease.
摘要
氧化应激与轻度认知障碍（MCI）和阿尔茨海默病（AD）的发病及进展相关。AD和MCI患者的大脑及血浆表现出广泛的氧化应激，其指标包括蛋白质氧化、脂质过氧化、自由基形成、DNA氧化以及抗氧化剂减少。最丰富的内源性抗氧化剂谷胱甘肽在对抗氧化应激中发挥重要作用。氧化型谷胱甘肽与还原型谷胱甘肽的比例被用作氧化应激强度的衡量指标。长期以来，抗氧化剂一直被视为减缓AD进展的一种方法。在本综述中，我们重点关注通过N-乙酰半胱氨酸（NAC）和γ-谷氨酰半胱氨酸乙酯（GCEE）提高谷胱甘肽水平，将其作为治疗阿尔茨海默病的一种潜在方法。本文是名为“疾病中的抗氧化剂与抗氧化治疗”的特刊的一部分。
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