Kuroda Research Unit for Affiliative Social Behavior, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-Shi, Saitama, Japan.
Behav Brain Res. 2012 Jun 1;231(2):366-70. doi: 10.1016/j.bbr.2011.10.008. Epub 2011 Oct 14.
In this paper we present a number of studies, some with humans and some with animals that have been directly influenced by the work of Philip Teitelbaum. As appropriate for a festschrift, we integrate a number of contributions from different fields (specifically, clinical psychopathology and neurobiology) and present the studies, not so much chronologically, but in ways that illustrate some of the key lessons that we have learned from Philip Teitelbaum. We would summarize these lessons as follows: (1) Complex and precise tools are required to assess the complexity of specific behaviors; using simplified tools will bias our understanding of the behavior itself. (2) Studying a specific behavior in atypical brain conditions is required to fully understand that behavior and how the brain controls it. (3) Considering the evolutionary basis of human behavior, studying corresponding behaviors in other mammalian species is required to strengthen and deepen our knowledge of specific human behaviors. In this paper we describe studies on motor development in humans and mice and their implication for the diagnosis of autism and early parental care that illustrate these three lessons.
在本文中，我们呈现了一系列的研究，其中一些是针对人类，另一些则是针对动物，这些研究直接受到了 Philip Teitelbaum 的工作的影响。作为一本纪念文集，我们整合了来自不同领域的多项贡献（具体来说，是临床精神病理学和神经生物学），并以能够说明我们从 Philip Teitelbaum 那里学到的一些关键经验的方式呈现这些研究，而不是按照时间顺序。我们可以将这些经验总结如下：（1）需要复杂而精确的工具来评估特定行为的复杂性；使用简化的工具会使我们对行为本身的理解产生偏见。（2）研究异常大脑条件下的特定行为是充分理解该行为以及大脑如何控制它所必需的。（3）考虑到人类行为的进化基础，研究其他哺乳动物物种的相应行为是增强和深化我们对特定人类行为的了解所必需的。在本文中，我们描述了人类和老鼠的运动发育研究，以及它们对自闭症和早期父母养育的诊断的启示，这些研究说明了这三个经验。
