Tufts University, School of Medicine, Boston, Massachusetts, USA.
Adv Skin Wound Care. 2011 Nov;24(11):524-32; quiz 533-4. doi: 10.1097/01.ASW.0000407648.89961.a6.
The objective of the study was to inform wound care practitioners of mesenchymal stem cell application for nonhealing wounds. Recent advances in delivery systems are also discussed in order to highlight potential improvements toward clinical application of stem cell therapy for chronic wounds.
MEDLINE and PubMed Central were searched for scientific studies regarding the use of mesenchymal stem cells and delivery systems in wound healing.
Preclinical studies using stem cells as therapeutic modality for chronic wounds were selected for this review.
Information on study design, sample size and characteristics, stem cell source, type of delivery systems, and rate and time of wound closure was abstracted.
Application of mesenchymal stem cells improved wound healing in experimental and clinical settings. Advances in stem cell therapy and delivery vehicles offer promising alternatives to current limited therapeutic modalities for chronic wounds.
Stem cell therapy has recently emerged as a promising therapeutic strategy for nonhealing wounds. Further research is needed to evaluate the relationship between the various delivery systems and stem cells in order to maximize their therapeutic effects. Development of novel delivery vehicles for stem cells can open new opportunities for more effective cell therapy of chronic wounds.
本研究旨在向伤口护理从业者介绍间充质干细胞在难愈性伤口中的应用。文中还讨论了最近在输送系统方面的进展，以突出干细胞疗法在慢性伤口临床应用方面的潜在改进。
检索了 MEDLINE 和 PubMed Central 中关于间充质干细胞和输送系统在伤口愈合中的应用的科学研究。
本综述选取了将干细胞作为慢性伤口治疗方法的临床前研究。
提取了研究设计、样本量和特征、干细胞来源、输送系统类型以及伤口闭合的速度和时间等信息。
间充质干细胞的应用改善了实验和临床环境中的伤口愈合。在干细胞治疗和输送载体方面的进展为慢性伤口目前有限的治疗方式提供了有前景的替代方法。
干细胞疗法最近已成为治疗难愈性伤口的一种很有前途的治疗策略。需要进一步研究以评估各种输送系统与干细胞之间的关系，从而最大程度地发挥其治疗效果。开发新型干细胞输送载体可为慢性伤口的更有效细胞治疗开辟新的机会。
