Ayala-Ruíz A, Valenzuela S
División de Investigación Biomédica, Instituto Nacional de Perinatología.
Gac Med Mex. 1990 Mar-Apr;126(2):108-13.
Evidence obtained from the study of polycystic ovarian disease in the female is reviewed. The etiology of this problem remains unknown, in spite of advances achieved by means of biochemical and morphologic studies. No correlation has been observed between histological findings and the pituitary or gonadal hormone production. However, an abnormal hypothalamic-pituitary-gonadal interaction prevails, characterized by a increased LH-FSH ratio associated with high level of androgens, mainly androstenedione. The pituitary reserve test performed with potent GnRH agonists have confirmed the hyper-response of LH along with that of androstenedione, as well as augmentation of 17-hydroxyprogesterone. Since the pattern of gonadotropins and steroid hormone secretion in women with polycystic ovarian disease resembles that seen in normal men, the basic alteration may well consist in a functionally "masculinized" hypothalamus.
本文综述了从女性多囊卵巢疾病研究中获得的证据。尽管通过生化和形态学研究取得了进展，但该问题的病因仍然不明。组织学发现与垂体或性腺激素分泌之间未观察到相关性。然而，下丘脑-垂体-性腺相互作用异常普遍存在，其特征是促黄体生成素（LH）与促卵泡生成素（FSH）的比例增加，同时伴有高水平的雄激素，主要是雄烯二酮。使用强效促性腺激素释放激素（GnRH）激动剂进行的垂体储备试验证实了LH以及雄烯二酮的高反应性，同时17-羟孕酮也增加。由于多囊卵巢疾病女性的促性腺激素和类固醇激素分泌模式与正常男性相似，基本改变很可能在于功能上“男性化”的下丘脑。
