Lecomte P, Kuttenn F, Mauvais-Jarvis P
Nouv Presse Med. 1978 Feb 4;7(5):355-6, 361-2.
Recent developments have occurred in the understanding of the physiopathology of polycystic ovary (Stein-Leventhal) syndrome. The authors describe in particular the present bio-chemical definition of so-called type I polycystic ovary syndrome: very high and anarchical secretion of LH by the pituitary, explosive response of LH during the LH-RH test, contrasting with normal levels of FSH under basal conditions and after stimulation with LH-RH. In the polycystic ovary, positive and negative feedback exerted by oestrogens at the level of the hypothalamus are intact. In particular, the administration of clomiphene results, in the majority of cases, in ovulation in patients with this disorder. The mechanisms (ovarian hyperproduction of androstenedione, increased transformation of androstenedione into testosterone then dihydrotestosterone and into androstanediol) responsible for the development of hyperandrogenism during polycystic ovary syndrome are also analysed.
近年来，人们对多囊卵巢（斯坦因-莱文塔尔）综合征的生理病理学有了新的认识。作者特别描述了所谓的I型多囊卵巢综合征目前的生化定义：垂体促黄体生成素（LH）分泌极高且无规律，在LH释放激素（LH-RH）试验中LH呈爆发性反应，而基础状态下及LH-RH刺激后促卵泡生成素（FSH）水平正常。在多囊卵巢中，雌激素在下丘脑水平发挥的正负反馈作用是完整的。特别是，在大多数情况下，给予克罗米芬可使患有这种疾病的患者排卵。文中还分析了多囊卵巢综合征期间雄激素过多症发生发展的机制（卵巢雄烯二酮过度产生，雄烯二酮向睾酮、然后向双氢睾酮以及向雄烷二醇的转化增加）。
