Department of Pathology, JSS Medical College (constituent college of JSS University), Mysore, Karnataka, India.
Indian J Dermatol Venereol Leprol. 2011 Nov-Dec;77(6):695-8. doi: 10.4103/0378-6323.86484.
Acral cutaneous metastasis is a rare phenomenon. A 38-year-old woman presented with painful lesions in the left hand since 1 month. On examination, multiple painful, erythematous, lobulated plaques and nodules were present over the palmar aspect of the finger tips and thenar eminence. Biopsy of the nodule revealed lobules of small pleomorphic epithelial cells arranged in singles, small nests, cords and small abortive luminal pattern in an abundant mucoid matrix, suggestive of metastatic mucinous carcinoma. Past history revealed that the patient had undergone bilateral mastectomy for carcinoma breast. Diagnosis of cutaneous metastases is based on clinical history and histopathological examination. Identification of the primary tumor is very important for prompt treatment and prognosis. The rarity of pure acral cutaneous metastasis and its possible pathogenetic mechanisms are discussed.
肢端皮肤转移是一种罕见的现象。一位 38 岁女性 1 个月前开始出现左手疼痛性皮损。体格检查发现,手指掌侧和大鱼际处有多个疼痛性、红斑性、分叶状斑块和结节。结节活检显示,小而形态多样的上皮细胞呈小叶状、小结节状、索状和小的无腔性结构排列在丰富的黏液基质中,提示转移性黏液癌。既往史显示,该患者曾因乳腺癌行双侧乳房切除术。皮肤转移的诊断基于临床病史和组织病理学检查。确定原发肿瘤对及时治疗和预后非常重要。本文讨论了纯肢端皮肤转移的罕见性及其可能的发病机制。