Gillard Jonathan
Cardiff School of Mathematics, Cardiff University, Cardiff, Wales, UK.
Stat Methods Med Res. 2015 Dec;24(6):788-802. doi: 10.1177/0962280211426617. Epub 2011 Oct 19.
This article re-examines parametric methods for the calculation of time specific reference intervals where there is measurement error present in the time covariate. Previous published work has commonly been based on the standard ordinary least squares approach, weighted where appropriate. In fact, this is an incorrect method when there are measurement errors present, and in this article, we show that the use of this approach may, in certain cases, lead to referral patterns that may vary with different values of the covariate. Thus, it would not be the case that all patients are treated equally; some subjects would be more likely to be referred than others, hence violating the principle of equal treatment required by the International Federation for Clinical Chemistry. We show, by using measurement error models, that reference intervals are produced that satisfy the requirement for equal treatment for all subjects.
本文重新审视了在时间协变量存在测量误差时计算特定时间参考区间的参数方法。先前发表的工作通常基于标准的普通最小二乘法，并在适当情况下进行加权。事实上，当存在测量误差时，这是一种不正确的方法，在本文中，我们表明使用这种方法在某些情况下可能会导致转诊模式随协变量的不同值而变化。因此，并非所有患者都能得到平等对待；一些受试者比其他受试者更有可能被转诊，从而违反了国际临床化学联合会要求的平等治疗原则。我们通过使用测量误差模型表明，所产生的参考区间满足对所有受试者平等治疗的要求。
