Abdullin G Z, Garina I A, Shaliapina V G
Fiziol Zh SSSR Im I M Sechenova. 1987 May;73(5):680-4.
ACTH (1 unit per 1 rat) induced a 6-fold increase of the corticosterone synthesis in adrenals and a 2-fold increase of its secretion into the blood. Met-enkephalin (15 micrograms/kg) also increase the corticosterone secretion, the level of the hormone in the blood, however, becoming even lower. Combined action of these two substances involved a greater increase of the hormone concentration in the gland than in case of each of them separately. The hormone content in the blood remained low in this case, too. In perfusion of an isolated adrenal gland with met-enkephalin (15 micrograms/ml), no increase in the corticosterone concentration was observed either in the perfusate samples. The data obtained suggest that met-enkephalin activates synthesis of corticosteroids, on the one hand, and inhibits their secretion into the blood, on the other hand, whereas ACTH activates both these processes.
促肾上腺皮质激素（每只大鼠1单位）可使肾上腺中皮质酮的合成增加6倍，并使其分泌到血液中的量增加2倍。甲硫氨酸脑啡肽（15微克/千克）也会增加皮质酮的分泌，然而，血液中该激素的水平却变得更低。这两种物质的联合作用使腺体中激素浓度的增加幅度大于它们各自单独作用时的情况。此时血液中的激素含量也仍然很低。在用甲硫氨酸脑啡肽（15微克/毫升）灌注离体肾上腺时，在灌注液样本中也未观察到皮质酮浓度增加。所获得的数据表明，一方面甲硫氨酸脑啡肽激活皮质类固醇的合成，另一方面抑制它们分泌到血液中，而促肾上腺皮质激素则激活这两个过程。
