Boscencu Rica, Ilie Mihaela, Socoteanu Radu
Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia Street, Bucharest 020956, Romania; E-Mail:
Int J Mol Sci. 2011;12(9):5552-64. doi: 10.3390/ijms12095552. Epub 2011 Aug 30.
The paper presents spectral studies of some unsymmetrical A(3)B tetrapyrrolic, porphyrin-type complexes with Cu(II) and Zn(II) in different solvents and micellar media aimed at estimating their properties in connection with the living cell. The results indicate that the position of the absorption and emission peaks is mostly influenced by the central metal ion and less by the environmental polarity or the peripheric substituents of the porphyrinic core. The comparison between the overall absorption and emission spectra of the compounds in methanol or cyclohexane vs. direct and reverse Triton X micellar systems, respectively, suggests for all compounds the localization at the interface between the polyethylene oxide chains and the tert-octyl-phenyl etheric residue of the Triton X-100 molecules. These findings could be important when testing the compounds embedded in liposomes or other delivery systems to the targeted cell.
本文介绍了一些不对称A(3)B四吡咯类卟啉型配合物与铜(II)和锌(II)在不同溶剂和胶束介质中的光谱研究，旨在评估它们与活细胞相关的性质。结果表明，吸收峰和发射峰的位置主要受中心金属离子影响，受环境极性或卟啉核外围取代基的影响较小。分别比较化合物在甲醇或环己烷与直接和反向 Triton X 胶束体系中的整体吸收光谱和发射光谱，表明所有化合物都定位在 Triton X-100 分子的聚环氧乙烷链与叔辛基苯基醚残基之间的界面处。在测试包封于脂质体或其他靶向细胞递送系统中的化合物时，这些发现可能具有重要意义。
