Mereles Derliz, Hunstein Werner
Department of Cardiology, Angiology and Pneumology, University of Heidelberg, D-69120 Heidelberg, Germany.
Int J Mol Sci. 2011;12(9):5592-603. doi: 10.3390/ijms12095592. Epub 2011 Aug 31.
Epigallocatechin-3-gallate (EGCG), the main and most significant polyphenol in green tea, has shown numerous health promoting effects acting through different pathways, as antioxidant, anti-inflammatory and anti-atherogenic agent, showing gene expression activity, functioning through growth factor-mediated pathways, the mitogen-activated protein kinase-dependent pathway, the ubiquitin/proteasome degradation pathway, as well as eliciting an amyloid protein remodeling activity. However, epidemiological inferences are sometimes conflicting and in vitro and in vivo studies may seem discrepant. Current knowledge on how to enhance bioavailability could be the answer to some of these issues. Furthermore, dose levels, administration frequency and potential side effects remain to be examined.
表没食子儿茶素-3-没食子酸酯（EGCG）是绿茶中主要且最重要的多酚类物质，已显示出通过不同途径发挥的多种促进健康的作用，如作为抗氧化剂、抗炎剂和抗动脉粥样硬化剂，具有基因表达活性，通过生长因子介导的途径、丝裂原活化蛋白激酶依赖性途径、泛素/蛋白酶体降解途径发挥作用，以及引发淀粉样蛋白重塑活性。然而，流行病学推断有时相互矛盾，体外和体内研究结果可能存在差异。目前关于如何提高生物利用度的知识可能是解决其中一些问题的答案。此外，剂量水平、给药频率和潜在副作用仍有待研究。
