The Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan, USA.
Adv Clin Chem. 2011;53:155-77. doi: 10.1016/b978-0-12-385855-9.00007-2.
Cancer-preventive effects of tea polyphenols, especially epigallocatechin-3-gallate (EGCG), have been demonstrated by epidemiological, preclinical, and clinical studies. Green tea polyphenols such as EGCG have the potential to affect multiple biological pathways, including gene expression, growth factor-mediated pathways, the mitogen-activated protein kinase-dependent pathway, and the ubiquitin/proteasome degradation pathway. Therefore, identification of the molecular targets of EGCG should greatly facilitate a better understanding of the mechanisms underlying its anticancer and cancer-preventive activities. Performing structure-activity relationship (SAR) studies could also greatly enhance the discovery of novel tea polyphenol analogs as potential anticancer and cancer-preventive agents. In this chapter, we review the relevant literature as it relates to the effects of natural and synthetic green tea polyphenols and EGCG analogs on human cancer cells and their potential molecular targets as well as their antitumor effects. We also discuss the implications of green tea polyphenols in cancer prevention.
茶多芬具有预防癌症的作用，尤其是表没食子儿茶素没食子酸酯（EGCG），这已被流行病学、临床前和临床研究证明。绿茶多芬，如 EGCG，有可能影响多种生物途径，包括基因表达、生长因子介导的途径、丝裂原激活蛋白激酶依赖性途径和泛素/蛋白酶体降解途径。因此，确定 EGCG 的分子靶标应极大地促进对其抗癌和防癌活性机制的更好理解。进行结构-活性关系（SAR）研究也可以极大地促进新型茶多芬类似物的发现，作为潜在的抗癌和防癌剂。在本章中，我们回顾了与天然和合成绿茶多芬和 EGCG 类似物对人类癌细胞的影响及其潜在的分子靶标以及它们的抗肿瘤作用相关的相关文献。我们还讨论了绿茶多芬在癌症预防中的意义。
