Sochacka Klaudia, Lachowicz-Wiśniewska Sabina
Faculty of Medicine and Health Science, University of Kalisz, pl. W. Bogusławskiego 2, 62-800 Kalisz, Poland.
Molecules. 2025 Jun 30;30(13):2827. doi: 10.3390/molecules30132827.
Obesity and depression frequently coexist, sharing overlapping molecular pathways such as inflammation, oxidative stress, gut microbiota dysbiosis, and neuroendocrine dysfunction. Recent research highlights the therapeutic potential of plant-derived bioactive compounds in targeting these shared mechanisms. This scoping review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and included 261 peer-reviewed studies identified through PubMed, Scopus, and the Web of Science up to December 2024. Studies were screened based on predefined inclusion and exclusion criteria. This review synthesizes data from peer-reviewed studies, including both preclinical and clinical investigations, focusing on polyphenols, flavonoids, alkaloids, and other phytochemicals with anti-inflammatory, antioxidant, neuroprotective, and metabolic effects. Compounds such as quercetin, epigallocatechin gallate (EGCG), resveratrol, curcumin, anthocyanins, and luteolin demonstrate promise in modulating adenosine monophosphate-activated protein kinase (AMPK), brain-derived neurotrophic factor (BDNF), nuclear factor kappa B (NF-κB), and gut-brain axis pathways. Our scoping review, conducted in accordance with PRISMA guidelines, identifies promising combinations and mechanisms for integrative phytotherapy. These findings underscore the potential of botanical strategies in developing future interventions for metabolic and mood comorbidities.
肥胖和抑郁症常常并存，共享一些重叠的分子途径，如炎症、氧化应激、肠道微生物群失调和神经内分泌功能障碍。最近的研究突出了植物源性生物活性化合物针对这些共同机制的治疗潜力。本综述遵循系统评价和Meta分析的首选报告项目（PRISMA）指南，纳入了截至2024年12月通过PubMed、Scopus和科学网检索到的261项经同行评审的研究。研究根据预先确定的纳入和排除标准进行筛选。本综述综合了同行评审研究的数据，包括临床前和临床研究，重点关注具有抗炎、抗氧化、神经保护和代谢作用的多酚、黄酮类、生物碱和其他植物化学物质。槲皮素、表没食子儿茶素没食子酸酯（EGCG）、白藜芦醇、姜黄素、花青素和木犀草素等化合物在调节腺苷单磷酸激活蛋白激酶（AMPK）、脑源性神经营养因子（BDNF）、核因子κB（NF-κB）和肠-脑轴途径方面显示出前景。我们按照PRISMA指南进行的综述确定了综合植物疗法的有前景的组合和机制。这些发现强调了植物策略在开发未来代谢和情绪共病干预措施方面的潜力。
