热休克蛋白 90 与致癌病毒的相互作用：对病毒癌症治疗学的启示。
Interactions between Hsp90 and oncogenic viruses: implications for viral cancer therapeutics.
出版信息
Am J Cancer Res. 2011;1(6):763-72. Epub 2011 Jun 5.
Abstract
Oncogenic viruses are the etiologic agents for a significant proportion of human cancers, but effective therapies and preventative strategies are lacking for the majority of virus-associated cancers. Targeting of virus-induced signal transduction or virus-host protein interactions may offer novel therapeutic strategies for viral cancers. Heat shock protein 90 (Hsp90) is a well-characterized, multifunctional molecular chaperone involved in regulation of signal transduction, transcriptional activation, oncogenic protein stabilization, and neovascularization-pathogenic elements relevant to viral cancer pathogenesis. This review will summarize mechanistic concepts involving regulation of viral oncogenesis by both intracellular and extracellular Hsp90, as well as current therapeutic implications of these data.
摘要
致癌病毒是人类癌症的重要病因，但对于大多数与病毒相关的癌症，缺乏有效的治疗方法和预防策略。针对病毒诱导的信号转导或病毒-宿主蛋白相互作用可能为病毒癌症提供新的治疗策略。热休克蛋白 90（Hsp90）是一种特征明确的多功能分子伴侣，参与信号转导、转录激活、致癌蛋白稳定和新血管生成-与病毒癌症发病机制相关的致病因素的调节。这篇综述将总结涉及细胞内和细胞外 Hsp90调节病毒致癌的机制概念，以及这些数据的当前治疗意义。
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