麻杏石甘汤及其主要组成药材挥发油的GC-MS对比分析
[Comparative analysis of volatile oils of Mahuang Fuzi Xixin decoction and its major constituted herbs by GC-MS].
作者信息
Liang Shao-yu, Tan Xiao-mei, Chen Fei-long, Luo Jia-bo
机构信息
School of Traditional Chinese Medicine, Southern Medical University/Guangdong Key Lab of Traditional Chinese Medicine, Guangzhou 510515, China.
出版信息
Zhong Yao Cai. 2011 Jun;34(6):896-901.
OBJECTIVE
To evaluate the correlativity between volatile oils of Mahuang Fuzi Xixin decoction and its major constituted herbs in composition and proportion.
METHODS
The chemical compositions of volatile oils obtained by wet distillation from Mahuang Fuzi Xixin decoction and its major constituted herbs (Herba Ephedrae, processed Radix Aconiti Lateralis, Herba Asari) were analyzed by GC-MS.
RESULTS
44 volatile components of Mahuang Fuzi Xixin decoction were identified, which mainly derived from its constituted herbs Mahuang and Xixin. 68, 8, 39 volatile components were respectively identified from volatile oils of Herba Epherae, processd Radix Aconiti Lateralis and Herba Asari. There were apparent changes in composition and proportion between volatile oils of Mahuang Fuzi Xixin decoction and its major constituted herbs.
CONCLUSION
There are apparent changes not only in quantity but also in quality between decoction and its major constituted herbs. Meanwhile any changes in composition may lead to a change in efficacy.
目的
评价麻黄附子细辛汤挥发油与其主要组成药材在成分及比例上的相关性。
方法
采用水蒸气蒸馏法提取麻黄附子细辛汤及其主要组成药材（麻黄、制附子、细辛）的挥发油，并用气相色谱-质谱联用仪（GC-MS）分析其化学成分。
结果
鉴定出麻黄附子细辛汤挥发油中的44个挥发性成分，这些成分主要来源于其组成药材麻黄和细辛。从麻黄、制附子、细辛挥发油中分别鉴定出68个、8个、39个挥发性成分。麻黄附子细辛汤挥发油与其主要组成药材在成分及比例上有明显变化。
结论
汤剂与其主要组成药材不仅在量上而且在质上都有明显变化。同时，成分的任何变化都可能导致药效的改变。
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