阿达木单抗治疗期间发生的结节病相关性葡萄膜炎。
Sarcoid-related uveitis occurring during adalimumab therapy.
出版信息
Ocul Immunol Inflamm. 2012 Feb;20(1):59-60. doi: 10.3109/09273948.2011.623213. Epub 2011 Oct 21.
PURPOSE
To report the first case of sarcoid-related uveitis in a patient receiving adalimumab.
DESIGN
Case report.
METHODS
A 61-year-old woman with rheumatoid arthritis treated with adalimumab for 4 years presented with a 1-year history of bilateral panuveitis with venous vasculitis and peripheral multifocal choroiditis. A small papular lesion was found on her forehead, which upon biopsy showed noncaseating granulomas. No systemic involvement was observed.
RESULTS
An ophtalmological and clinical improvement was seen after (TNF) antagonist withdrawal plus a course of prednisone.
CONCLUSIONS
Ophthalmologists should know that a sarcoid-like granulomatosis can develop during TNFα blockade therapy.
目的
报告首例接受阿达木单抗治疗的患者发生与结节病相关的葡萄膜炎。
设计
病例报告。
方法
一名 61 岁女性，患有类风湿关节炎，接受阿达木单抗治疗 4 年，出现双侧全葡萄膜炎伴静脉血管炎和周边多发性脉络膜炎，病史 1 年。患者额头上发现一个小丘疹性病变，活检显示为非坏死性肉芽肿。未观察到系统受累。
结果
（TNF）拮抗剂停药加用泼尼松治疗后，眼部和临床症状均有改善。
结论
眼科医生应该知道，在 TNFα 阻断治疗期间可能会发生类结节病样肉芽肿病。
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