衰老与体外肾上腺皮质对促肾上腺皮质激素（ACTH）和环磷酸腺苷（cAMP）反应性的相互作用。

Interaction of aging with in vitro adrenocortical responsiveness to ACTH and cyclic AMP.

作者信息

Pritchett J F, Sartin J L, Marple D N, Harper W L, Till M L

出版信息

Horm Res. 1979;10(2-3):96-103. doi: 10.1159/000178993.

DOI:10.1159/000178993

Abstract

In vitro adrenal accumulation of cyclic 3'5'-adenosine monophosphate (cyclic AMP) and release of corticosterone in response to adrenocorticotropic hormone (ACTH), cyclic AMP or theophylline was assessed in 60- and 340-day-old male rats. Adrenal tissue from mature animals secreted significantly smaller quantities of corticosterone in response to ACTH, theophylline or cyclic AMP. Additionally, mature tissue accumulated significantly less cyclic AMP after treatment with ACTH or a combination of ACTH and theophylline. The data suggest an age-related refractoriness of adrenal cortical tissue to ACTH which may in part be related to decreased availability of and/or sensitivity to cyclic AMP.

摘要

在60日龄和340日龄的雄性大鼠中，评估了体外肾上腺对促肾上腺皮质激素（ACTH）、环磷酸腺苷（cAMP）或茶碱的反应中环磷酸腺苷的积累以及皮质酮的释放。成熟动物的肾上腺组织对ACTH、茶碱或环磷酸腺苷的反应分泌的皮质酮量显著减少。此外，成熟组织在用ACTH或ACTH与茶碱联合处理后积累的环磷酸腺苷显著减少。数据表明肾上腺皮质组织对ACTH存在与年龄相关的不应性，这可能部分与环磷酸腺苷的可用性降低和/或敏感性降低有关。

相似文献

1

Interaction of aging with in vitro adrenocortical responsiveness to ACTH and cyclic AMP.衰老与体外肾上腺皮质对促肾上腺皮质激素（ACTH）和环磷酸腺苷（cAMP）反应性的相互作用。

Horm Res. 1979;10(2-3):96-103. doi: 10.1159/000178993.

2

Aging of the rat adrenocortical cell: response to ACTH and cyclic AMP in vitro.大鼠肾上腺皮质细胞的衰老：体外对促肾上腺皮质激素（ACTH）和环磷酸腺苷（cAMP）的反应

J Gerontol. 1983 Mar;38(2):130-6. doi: 10.1093/geronj/38.2.130.

3

Differential effects of aging on adrenocorticotropin receptors, adenosine 3'5'-monophosphate response, and corticosterone secretion in adrenocortical cells from Sprague-Dawley rats.衰老对Sprague-Dawley大鼠肾上腺皮质细胞中促肾上腺皮质激素受体、3',5'-环磷酸腺苷反应及皮质酮分泌的不同影响。

Endocrinology. 1986 Nov;119(5):2206-13. doi: 10.1210/endo-119-5-2206.

4

Effect of dexamethasone on steroidogenesis and on adrenocortical cyclic AMP and cyclic GMP responses to ACTH.地塞米松对类固醇生成以及肾上腺皮质环磷酸腺苷和环磷酸鸟苷对促肾上腺皮质激素反应的影响。

Horm Metab Res. 1982 Oct;14(10):547-50. doi: 10.1055/s-2007-1019073.

5

Effects of ACTH and its O-nitrophenyl sulphenyl derivative on adrenocortical function in vivo.促肾上腺皮质激素（ACTH）及其邻硝基苯硫基衍生物对体内肾上腺皮质功能的影响。

Acta Endocrinol (Copenh). 1976 Jul;82(3):587-99. doi: 10.1530/acta.0.0820587.

6

Lack of steroidogenic response to cyclic AMP and ACTH in adrenal cells from rats bearing the MtTF4 tumor.携带MtTF4肿瘤的大鼠肾上腺细胞中对环磷酸腺苷和促肾上腺皮质激素缺乏类固醇生成反应。

Arch Int Pharmacodyn Ther. 1975 Oct;217(2):309-21.

7

The action of adenosine on steroidogenesis in isolated rat adrenocortical cells.腺苷对分离的大鼠肾上腺皮质细胞类固醇生成的作用。

J Steroid Biochem. 1978 Oct;9(10):973-7. doi: 10.1016/0022-4731(78)90060-2.

8

In vitro tropic action of ACTH upon adrenocortical cyclic nucleotide (cAMP, cGMP) production and corticosterone output in blue (Prionace glauca Linnaeus) and in mako (Isurus oxyrinchus Rafinesque) sharks.促肾上腺皮质激素对蓝鲨（Prionace glauca Linnaeus）和灰鲭鲨（Isurus oxyrinchus Rafinesque）肾上腺皮质环核苷酸（cAMP、cGMP）生成及皮质酮分泌的体外向性作用。

Gen Comp Endocrinol. 1978 Sep;36(1):161-9. doi: 10.1016/0016-6480(78)90061-8.

9

Effects of theophylline on corticosterone secretory and adrenal growth response to ACTH in vivo.茶碱对体内皮质酮分泌及肾上腺对促肾上腺皮质激素生长反应的影响。

Acta Physiol Acad Sci Hung. 1971;40(2):229-33.

10

Adrenocortical responses to adrenocorticotrophin in the rat.大鼠肾上腺皮质对促肾上腺皮质激素的反应。

Can J Physiol Pharmacol. 1980 Nov;58(11):1279-85. doi: 10.1139/y80-194.

引用本文的文献

1

Variations with age in the adrenocortical responses of mallard ducks (Anas platyrhynchos) consuming petroleum-contaminated food.食用受石油污染食物的绿头鸭（Anas platyrhynchos）肾上腺皮质反应随年龄的变化。

Bull Environ Contam Toxicol. 1982 Aug;29(2):146-52. doi: 10.1007/BF01606142.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。