Department of Radiation Sciences, Oncology, Umeå University Hospital, Umeå, Sweden.
Acta Oncol. 2012 Mar;51(3):325-32. doi: 10.3109/0284186X.2011.616284. Epub 2011 Oct 21.
Patient outcome from glioma may be influenced by germline variation. Considering the importance of DNA repair in cancer biology as well as in response to treatment, we studied the relationship between 1458 SNPs, which captured the majority of the common genetic variation in 136 DNA repair genes, in 138 glioblastoma samples from Sweden and Denmark. We confirmed our findings in an independent cohort of 121 glioblastoma patients from the UK. Our analysis revealed nine SNPs annotating MSH2, RAD51L1 and RECQL4 that were significantly (p < 0.05) associated with glioblastoma survival.
胶质母细胞瘤患者的预后可能受种系变异的影响。鉴于 DNA 修复在癌症生物学以及对治疗的反应中的重要性，我们研究了在来自瑞典和丹麦的 138 例胶质母细胞瘤样本中，136 个 DNA 修复基因中的 1458 个 SNPs 的关系。我们在来自英国的 121 例胶质母细胞瘤患者的独立队列中证实了我们的发现。我们的分析显示，注释 MSH2、RAD51L1 和 RECQL4 的九个 SNP 与胶质母细胞瘤的生存显著相关（p < 0.05）。
