Department of Fetal-Maternal Medicine and Gynecology, Polish Mother's Memorial Hospital Research Institute, 281/289 Rzgowska Street, 93-338, Lodz, Poland,
Arch Microbiol. 2014 Jan;196(1):1-8. doi: 10.1007/s00203-013-0944-0. Epub 2013 Dec 14.
Lately, we can observe significant progress in understanding mechanism of DNA repair owing to fast methods of DNA sequence analysis from different organisms the revealing of structure and function of DNA repair proteins in prokaryota and eukaryota. The protozoan parasites survival depends on DNA repair systems. Better understanding of DNA repair systems can help in new antipathogen drug development. This review is aimed at updating our current knowledge of the various repair pathways by providing an overview of DNA repair genes regarding Toxoplasma gondii infections and the corresponding proteins, participating either directly in DNA repair, or in checkpoint control and signaling of DNA damage.
最近，由于从不同生物体中快速分析 DNA 序列的方法的出现，我们可以观察到对 DNA 修复机制的理解取得了重大进展，揭示了原核生物和真核生物中 DNA 修复蛋白的结构和功能。原生动物寄生虫的生存依赖于 DNA 修复系统。更好地了解 DNA 修复系统有助于开发新的抗病原体药物。本综述旨在通过概述与弓形虫感染相关的 DNA 修复基因及其相应的蛋白质，更新我们对各种修复途径的现有认识，这些蛋白质要么直接参与 DNA 修复，要么参与 DNA 损伤的检查点控制和信号转导。
