Department of Chemistry, School of Science, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
J Am Chem Soc. 2011 Nov 23;133(46):18550-3. doi: 10.1021/ja2080086. Epub 2011 Nov 2.
Considering the importance of the development of powerful green catalysts and the omnipresence of amide bonds in natural and synthetic compounds, we report here on reactions between alcohols and amines for amide bond formation in which heterogeneous gold and gold/iron, -nickel, or -cobalt nanoparticles are used as catalysts and molecular oxygen is used as terminal oxidant. Two catalysts show excellent activity and selectivity, depending on the type of alcohols used. A wide variety of alcohols and amines, including aqueous ammonia and amino acids, can be used for the amide synthesis. Furthermore, the catalysts can be recovered and reused several times without loss of activity.
考虑到开发高效绿色催化剂的重要性以及酰胺键在天然和合成化合物中的普遍存在，我们在此报告了醇和胺之间的反应，在这些反应中使用了多相金以及金/铁、金/镍或金/钴纳米粒子作为催化剂，分子氧作为末端氧化剂，用于酰胺键的形成。两种催化剂的活性和选择性取决于所使用的醇的类型，表现出优异的性能。各种醇和胺，包括氨水和氨基酸，都可用于酰胺的合成。此外，催化剂可以回收并重复使用多次而不损失活性。
