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可见光照氧化还原催化苄醇的酰胺化反应。

Visible-Light Photoredox-Catalyzed Amidation of Benzylic Alcohols.

机构信息

Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy.

Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.

出版信息

J Org Chem. 2020 Sep 18;85(18):11679-11687. doi: 10.1021/acs.joc.0c01320. Epub 2020 Jul 23.

DOI:10.1021/acs.joc.0c01320
PMID:32662268
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8009506/
Abstract

A new photocatalyzed route to amides from alcohols and amines mediated by visible light is presented. The reaction is carried out in ethyl acetate as a solvent. Ethyl acetate can be defined a green and bio-based solvent. The starting materials such as the energy source are easily available, stable, and inexpensive. The reaction has shown to be general and high yielding.

摘要

本文提出了一种新的可见光介导的由醇和胺合成酰胺的光催化方法。该反应在乙酸乙酯溶剂中进行。乙酸乙酯可定义为绿色和生物基溶剂。起始原料如能源易于获得、稳定且廉价。该反应具有通用性和高产率的特点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef5/8009506/d72dddf25903/jo0c01320_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef5/8009506/79f43dcbbcc2/jo0c01320_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef5/8009506/9c56bab30567/jo0c01320_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef5/8009506/d72dddf25903/jo0c01320_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef5/8009506/79f43dcbbcc2/jo0c01320_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef5/8009506/9c56bab30567/jo0c01320_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef5/8009506/d72dddf25903/jo0c01320_0003.jpg

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Metal-Free Transamidation of Secondary Amides by N-C Cleavage.无金属参与的通过 N-C 键断裂的仲酰胺的转酰胺化反应。
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