多效激酶枢纽如何介导 TNFR 超家族成员的特定信号转导？
How do pleiotropic kinase hubs mediate specific signaling by TNFR superfamily members?
机构信息
Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0375, USA.
出版信息
Immunol Rev. 2011 Nov;244(1):29-43. doi: 10.1111/j.1600-065X.2011.01060.x.
Abstract
Tumor necrosis factor receptor (TNFR) superfamily members mediate the cellular response to a wide variety of biological inputs. The responses range from cell death, survival, differentiation, proliferation, to the regulation of immunity. All these physiological responses are regulated by a limited number of highly pleiotropic kinases. The fact that the same signaling molecules are involved in transducing signals from TNFR superfamily members that regulate different and even opposing processes raises the question of how their specificity is determined. Regulatory strategies that can contribute to signaling specificity include scaffolding to control kinase specificity, combinatorial use of several signal transducers, and temporal control of signaling. In this review, we discuss these strategies in the context of TNFR superfamily member signaling.
摘要
肿瘤坏死因子受体（TNFR）超家族成员介导细胞对各种生物输入的反应。这些反应范围从细胞死亡、存活、分化、增殖到免疫调节。所有这些生理反应都受到少数高度多效性激酶的调节。事实上，相同的信号分子参与传递来自 TNFR 超家族成员的信号，这些信号调节不同甚至相反的过程，这就提出了一个问题，即它们的特异性是如何确定的。有助于信号特异性的调控策略包括支架以控制激酶特异性、几种信号转导物的组合使用以及信号传递的时间控制。在这篇综述中，我们将在 TNFR 超家族成员信号的背景下讨论这些策略。
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本文引用的文献
1
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Nature. 2011 Mar 31;471(7340):637-41. doi: 10.1038/nature09814.
2
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex.SHARPIN 是 NF-κB 激活线性泛素链组装复合物的一个组成部分。
Nature. 2011 Mar 31;471(7340):633-6. doi: 10.1038/nature09815.
3
Linear ubiquitination prevents inflammation and regulates immune signalling.线性泛素化可预防炎症并调节免疫信号转导。
Nature. 2011 Mar 31;471(7340):591-6. doi: 10.1038/nature09816.
4
IKK-dependent, NF-κB-independent control of autophagic gene expression.IKK 依赖性、NF-κB 非依赖性自噬基因表达的调控。
Oncogene. 2011 Apr 7;30(14):1727-32. doi: 10.1038/onc.2010.553. Epub 2010 Dec 13.
5
A single NFκB system for both canonical and non-canonical signaling.一个 NFκB 系统同时用于经典和非经典信号转导。
Cell Res. 2011 Jan;21(1):86-102. doi: 10.1038/cr.2010.161. Epub 2010 Nov 23.
6
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Nat Rev Mol Cell Biol. 2010 Oct;11(10):700-14. doi: 10.1038/nrm2970. Epub 2010 Sep 8.
7
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Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
8
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9
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10
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J Biol Chem. 2010 Feb 19;285(8):5347-60. doi: 10.1074/jbc.M109.076976. Epub 2009 Dec 28.
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