MRC Centre for Immune Regulation, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Immunol Rev. 2011 Nov;244(1):134-48. doi: 10.1111/j.1600-065X.2011.01057.x.
CD4(+) effector and memory T cells play a pivotal role in the development of both normal and pathogenic immune responses. This review focuses on the molecular and cellular mechanisms that regulate their development, with particular focus on the tumor necrosis factor superfamily members OX40 (TNFRSF4) and CD30 (TNFRSF8). We discuss the evidence that in mice, these molecular signaling pathways act synergistically to regulate the development of both effector and memory CD4(+) T cells but that the cells that regulate memory versus effector function are distinct, effectively allowing the independent regulation of the memory and effector CD4(+) T-cell pools.
CD4(+)效应器和记忆 T 细胞在正常和病理性免疫反应的发展中起着关键作用。这篇综述重点介绍了调节其发育的分子和细胞机制，特别关注肿瘤坏死因子超家族成员 OX40（TNFRSF4）和 CD30（TNFRSF8）。我们讨论了这样的证据，即在小鼠中，这些分子信号通路协同作用，调节效应器和记忆 CD4(+)T 细胞的发育，但调节记忆与效应功能的细胞是不同的，这有效地允许对记忆和效应 CD4(+)T 细胞池进行独立调节。
