Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester M139PL, UK.
Neuron. 2011 Oct 20;72(2):385-96. doi: 10.1016/j.neuron.2011.09.013.
Traditional neurological models of language were based on a single neural pathway (the dorsal pathway underpinned by the arcuate fasciculus). Contemporary neuroscience indicates that anterior temporal regions and the "ventral" language pathway also make a significant contribution, yet there is no computationally-implemented model of the dual pathway, nor any synthesis of normal and aphasic behavior. The "Lichtheim 2" model was implemented by developing a new variety of computational model which reproduces and explains normal and patient data but also incorporates neuroanatomical information into its architecture. By bridging the "mind-brain" gap in this way, the resultant "neurocomputational" model provides a unique opportunity to explore the relationship between lesion location and behavioral deficits, and to provide a platform for simulating functional neuroimaging data.
传统的语言神经学模型基于单一的神经通路（由弓状束支撑的背侧通路）。当代神经科学表明，前颞叶区域和“腹侧”语言通路也有重要贡献，但目前还没有实现双通道的计算模型，也没有对正常和失语症行为进行综合。“Lichtheim 2”模型是通过开发一种新的计算模型来实现的，该模型再现和解释了正常和患者的数据，同时将神经解剖学信息纳入其架构。通过这种方式弥合“心-脑”差距，由此产生的“神经计算”模型为探索损伤部位与行为缺陷之间的关系提供了独特的机会，并为模拟功能神经影像学数据提供了一个平台。
