Wang Huifang E, Gonzalez-Martinez Jorge, Jirsa Viktor, Chauvel Patrick, Alario F-Xavier, Liegeois-Chauvel Catherine
Faculté de Medécine, Institut de Neurosciences des Systèmes (INS), Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), 13005 Marseille, France.
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Entropy (Basel). 2025 May 27;27(6):566. doi: 10.3390/e27060566.
Functional connectivity and its dynamic reconfiguration during cognitive tasks offer valuable insights into the neural mechanisms underlying cognitive functions. The dorsal language stream plays a crucial role in linking auditory and visual information with motor functions during language-related tasks. In this study, we investigated the dynamic functional connectivity of brain regions within the dorsal stream across five cognitive tasks using invasive stereoelectroencephalography (SEEG) recordings from patients with drug-resistant epilepsy. Our results reveal distinguishable functional connectivity patterns across various cognitive tasks using clustering algorithms. Furthermore, we were able to identify specific cognitive tasks based on their unique functional connectivity signatures, with a median of accuracy 0.91. Additionally, we identified key brain regions with strong connectivity roles and high variability across tasks. We analyzed source (out-degree) and sink (in-degree) regions during the picture naming, ba/pa, and oddball tasks, highlighting both shared and task-specific connectivity patterns. Among the twenty or so brain regions displaying a median in- and out-degree > 0.5 during the three tasks, the middle frontal gyrus (MFG) was highly involved in all three, corroborating its critical role in cognition. In contrast, the left superior frontal gyrus (SFG) and the superior temporal gyrus appeared to be modulated specifically via the tasks, exhibiting greater activity during picture naming compared to the other tasks. These findings enhance our understanding of the dynamic connectivity profiles associated with cognitive processing within the dorsal stream.
认知任务期间的功能连接及其动态重构为认知功能背后的神经机制提供了有价值的见解。在与语言相关的任务中，背侧语言流在将听觉和视觉信息与运动功能联系起来方面起着关键作用。在本研究中，我们使用来自耐药性癫痫患者的侵入性立体脑电图（SEEG）记录，研究了背侧流内脑区在五项认知任务中的动态功能连接。我们的结果显示，使用聚类算法，在各种认知任务中存在可区分的功能连接模式。此外，我们能够根据其独特的功能连接特征识别特定的认知任务，准确率中位数为0.91。此外，我们确定了在任务中具有强连接作用和高变异性的关键脑区。我们分析了图片命名、ba/pa和oddball任务期间的源（出度）和汇（入度）区域，突出了共享和特定于任务的连接模式。在这三项任务中，在二十多个显示入度和出度中位数>0.5的脑区中，额中回（MFG）在所有三项任务中都高度参与，证实了其在认知中的关键作用。相比之下，左上额回（SFG）和颞上回似乎通过任务受到特异性调节，与其他任务相比，在图片命名期间表现出更大的活动。这些发现加深了我们对背侧流内与认知处理相关的动态连接概况的理解。
