Rolf Luft Centre for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
J Diabetes. 2012 Mar;4(1):47-54. doi: 10.1111/j.1753-0407.2011.00165.x.
India lacks comprehensive mortality data in individuals with diabetes. The present retrospective case-control study compared the causes of death in diabetic and non-diabetic inpatients in a tertiary care hospital in 2007.
Deaths in diabetic patients (n = 315) were compared with 307 randomly selected controls. Medical chart review established the primary cause of death, demographics, and clinical data. Data were summarized using descriptive statistics and comparative analyses were performed.
Of the 79 067 inpatient admissions during 2007, diabetes of any type was recorded for 6517 (8.2%). There were 2017 inpatient deaths registered, 315 (15.6%) in diabetic patients and 1702 (84.4%) in non-diabetic patients, corresponding to mortality rates of 48.3/1000 admissions for diabetic patients and 23.4/1000 admissions for non-diabetic patients. The mean duration of hospitalization prior to death in diabetic versus non-diabetic patients was 6.4 vs 7.7 days (P = 0.015). Causes of death in diabetic patients were vascular disease (38.4%), infection (34.3%), renal failure (8.9%), and malignancy (8.9%); diabetic patients had significantly higher odds of death from vascular disease (odds ratio [OR] 4.05, 95% confidence interval [CI] 2.67-6.16; P ≤ 0.0001), renal causes (OR 7.39, 95%CI 2.53-29.27; P ≤ 0.001) and infection (OR 1.61, 95% CI 1.12-2.32; P ≤ 0.0001). Comparing cases and controls after stratifying by age (<56 and ≥56 years), the greater odds of vascular death among diabetics remained significant in both age categories.
We report vascular disease as the leading cause of death among diabetic hospital inpatients in one tertiary care center in India, in contrast with previous hospital-based studies from India.
印度缺乏关于糖尿病患者的综合死亡率数据。本回顾性病例对照研究比较了 2007 年一家三级护理医院中糖尿病和非糖尿病住院患者的死亡原因。
将 315 例糖尿病患者的死亡病例与 307 例随机选择的对照进行比较。病历回顾确定了主要死亡原因、人口统计学和临床数据。使用描述性统计方法总结数据，并进行比较分析。
2007 年，79067 例住院患者中，记录到任何类型的糖尿病患者 6517 例（8.2%）。登记了 2017 例住院死亡病例，315 例（15.6%）发生在糖尿病患者中，1702 例（84.4%）发生在非糖尿病患者中，糖尿病患者的住院死亡率为 48.3/1000 人次，而非糖尿病患者的住院死亡率为 23.4/1000 人次。与非糖尿病患者相比，糖尿病患者死亡前的平均住院时间为 6.4 天 vs 7.7 天（P = 0.015）。糖尿病患者的死亡原因分别为血管疾病（38.4%）、感染（34.3%）、肾衰竭（8.9%）和恶性肿瘤（8.9%）；与非糖尿病患者相比，糖尿病患者死于血管疾病的风险显著更高（比值比[OR] 4.05，95%置信区间[CI] 2.67-6.16；P ≤ 0.0001）、肾脏疾病（OR 7.39，95%CI 2.53-29.27；P ≤ 0.001）和感染（OR 1.61，95%CI 1.12-2.32；P ≤ 0.0001）。在按年龄（<56 岁和≥56 岁）分层后，将病例与对照组进行比较，发现糖尿病患者血管死亡的风险仍然显著高于其他年龄组。
与印度之前的医院为基础的研究不同，我们报告称血管疾病是印度一家三级护理中心糖尿病住院患者死亡的主要原因。
