Papazafiropoulou A, Tentolouris N, Bousboulas S, Sotiropoulos A, Tamvakos E, Peppas T, Kardara M, Pappas S
3rd Department of Internal Medicine, General Hospital of Nikaia, Piraeus, Greece.
Exp Clin Endocrinol Diabetes. 2010 May;118(5):315-9. doi: 10.1055/s-0029-1241215. Epub 2010 Jan 12.
Subjects with type 2 diabetes mellitus (T2DM) have increased morbidity and mortality mainly due to macrovascular complications. In addition, diabetic patients show increased in-hospital admissions in comparison with nondiabetic patients. However, in-hospital mortality data for patients with T2DM are not available in our country. The aim of the present study was to examine mortality rates in diabetic compared to nondiabetic patients admitted to a tertiary hospital during a 10-year period (1998-2007).
We performed a retrospective analysis of mortality rates in patients with and without T2DM hospitalised in a tertiary care hospital during the years 1998-2007. Demographic characteristics, medical history and outcome were collected from the patients' medical records. Patients with type 1 diabetes were excluded from the analysis.
A total of 16 125 patients' records were studied (14 005 without diabetes and 2 120 with T2DM). In the total sample, 1 467 (9.1%) deaths were recorded. Mortality rates were higher in the diabetic than in the nondiabetic patients (11.2% versus 8.7%, respectively, p<0.001). Age of death did not differ between diabetic and nondiabetic patients (age+/-SD: 77.1+/-9.5 vs. 77.6+/-16.3 years, p=0.73). Median length of hospital stay was higher in the diabetic than in the nondiabetic patients (p=0.03). Mortality was higher in the diabetic in comparison with the nondiabetic females (59.9% vs. 52.7%, respectively, p=0.04), while no gender difference was found in males. Cerebrovascular disease was the commonest cause of death in both diabetic and nondiabetic patients (41.6% vs. 30.3%, p=0.001), followed by infections (23.1% vs. 21.7%, respectively, p=0.62). Death rates from malignancies were more common in the nondiabetic in comparison with the diabetic patients (18.8% vs. 4.2%, p<0.001). No significant differences were observed between the two study groups regarding mortality caused by cardiovascular events and chronic renal failure.
The present study showed that diabetic patients and especially females had increased in-hospital mortality compared with nondiabetic patients. Cerebrovascular disease and infections were the more common cause of death in both groups.
2型糖尿病（T2DM）患者的发病率和死亡率增加，主要归因于大血管并发症。此外，与非糖尿病患者相比，糖尿病患者的住院率更高。然而，我国尚无T2DM患者的住院死亡率数据。本研究的目的是调查在10年期间（1998 - 2007年）入住三级医院的糖尿病患者与非糖尿病患者的死亡率。
我们对1998年至2007年期间在一家三级护理医院住院的有或无T2DM患者的死亡率进行了回顾性分析。从患者的病历中收集人口统计学特征、病史和结局。1型糖尿病患者被排除在分析之外。
共研究了16125例患者的记录（14005例无糖尿病，2120例有T2DM）。在总样本中，记录了1467例（9.1%）死亡病例。糖尿病患者的死亡率高于非糖尿病患者（分别为11.2%和8.7%，p<0.001）。糖尿病患者和非糖尿病患者的死亡年龄无差异（年龄±标准差：77.1±9.5岁对77.6±16.3岁，p = 0.73）。糖尿病患者的中位住院时间高于非糖尿病患者（p = 0.03）。糖尿病女性的死亡率高于非糖尿病女性（分别为59.9%和52.7%，p = 0.04），而男性患者未发现性别差异。脑血管疾病是糖尿病患者和非糖尿病患者最常见的死亡原因（分别为41.6%和30.3%，p = 0.001），其次是感染（分别为23.1%和21.7%，p = 0.62）。非糖尿病患者的恶性肿瘤死亡率高于糖尿病患者（18.8%对4.2%，p<0.001）。在心血管事件和慢性肾衰竭导致的死亡率方面，两个研究组之间未观察到显著差异。
本研究表明，与非糖尿病患者相比，糖尿病患者尤其是女性患者的住院死亡率增加。脑血管疾病和感染是两组中更常见的死亡原因。
