Newcastle Sexual Health Services, New Croft Centre, Newcastle upon Tyne NE1 6ND, UK.
Contraception. 2011 Nov;84(5):465-77. doi: 10.1016/j.contraception.2011.04.002. Epub 2011 Jun 8.
BACKGROUND: Fear of adverse effects on subsequent fertility following reversible contraceptive use is an important concern for some women. STUDY DESIGN: We undertook a comprehensive and objective review of the literature for prospective studies reporting pregnancy rates in women following contraceptive cessation. One-year pregnancy rates and pregnancy outcomes are summarized. RESULTS: We identified and analyzed 17 studies according to preset criteria. Typical 1-year pregnancy rates following cessation of oral contraceptives or the levonorgestrel-releasing intrauterine system (LNG-IUS) ranged between about 79% and 96% and those for copper intrauterine devices (IUDs) were almost as high, ranging between about 71% and 91%. One-year pregnancy rates following cessation of contraceptive implants were between 77% and 86%, with one study showing a rate lower than 50%. For injectable contraceptives [(a) norethisterone enanthate and (b) 5 mg estradiol cypionate and 25 mg medroxyprogesterone (Cyclofem)], only two studies were reported, with 1-year pregnancy rates following cessation of 73% and 83%, respectively. There was no evidence of increased pregnancy complications or adverse fetal outcomes following cessation of any of the reversible methods reported. CONCLUSIONS: Overall, 1-year pregnancy rates following cessation of oral contraceptives, contraceptive implants and monthly injections, copper IUDs and the LNG-IUS are broadly similar to those reported following discontinuation of barrier methods or use of no contraceptive method.
背景:一些女性非常担心使用可逆避孕措施后会对随后的生育能力产生不良影响。
研究设计:我们对报道避孕停止后女性妊娠率的前瞻性研究进行了全面和客观的文献回顾。总结了 1 年的妊娠率和妊娠结局。
结果:我们根据预设标准确定并分析了 17 项研究。口服避孕药或左炔诺孕酮宫内节育系统(LNG-IUS)停药后 1 年的典型妊娠率在 79%至 96%之间,而含铜宫内节育器(IUD)的妊娠率也几乎相同,在 71%至 91%之间。避孕植入物停药后 1 年的妊娠率在 77%至 86%之间,有一项研究显示的妊娠率低于 50%。对于注射用避孕药[(a)己酸孕酮和(b)5 毫克雌二醇环戊丙酸酯和 25 毫克醋酸甲羟孕酮(Cyclofem)],仅报告了两项研究,停药后 1 年的妊娠率分别为 73%和 83%。没有证据表明停止使用任何报告的可逆方法会增加妊娠并发症或不良胎儿结局的风险。
结论:总体而言,口服避孕药、避孕植入物和每月注射、含铜 IUD 和 LNG-IUS 停药后 1 年的妊娠率与屏障方法停药或不使用任何避孕方法后报告的妊娠率大致相似。
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