Lähteenmäki P, Bardin C W, Elomaa K, Haukkamaa M, Kivijärvi A, Kuukankorpi A, Venhola M, Tuominen J
Department of Medical Chemistry, University of Helsinki, Finland.
Acta Obstet Gynecol Scand Suppl. 1997;164:69-74.
The levonorgestrel-releasing intrauterine system (LNg IUS) is a hormonal contraceptive that is used in the uterine cavity. To determine whether the reasons for choosing LNg IUS vs. copperreleasing intrauterine devices (Cu IUDs) differ and whether their performances are comparable, we carried out a retrospective study in Finland during the first years of LNg IUS use.
Gynecological and contraceptive histories of 626 LNg IUS and 626 Cu IUD users and the performance of the device were reviewed from patient records.
Women who accepted the LNg IUS were more likely than Cu IUD acceptors to have a history of menstrual bleeding of 6 days or more (44.4% vs. 28.4%), heavy bleeding (44.8% vs. 8.4%) and moderate or severe dysmenorrhea (15.9% vs. 7.5%). In both groups, 70% of the women had used Cu IUDs earlier. However, the LNg IUS acceptors had had more side effects during previous use of CU IUDs (58.2% vs. 28.8%). They also reported more side effects that resulted in discontinuation of a previous Cu IUD (39.4% vs. 10.1%). However, the 12-month life-table continuation rates of 80.6 (SE 1.9)% vs. 83.4 (SE 1.8)% were alike. Cu IUD users discontinued the current method more often because of problems of bleeding and unwanted pregnancy. Among those women who had previously discontinued a hormonal method because of hormonal side effects, there were no differences in the continuation rates of the two groups.
LNg IUS can be successfully used by women who cannot use a CU IUD or who have experienced hormonal side effects with oral contraceptives.
左炔诺孕酮宫内节育系统(LNG IUS)是一种用于宫腔的激素避孕器。为了确定选择LNG IUS与含铜宫内节育器(Cu IUD)的原因是否不同以及它们的性能是否可比,我们在芬兰LNG IUS使用的最初几年进行了一项回顾性研究。
从患者记录中回顾了626名LNG IUS使用者和626名Cu IUD使用者的妇科和避孕史以及器械的性能。
接受LNG IUS的女性比接受Cu IUD的女性更有可能有月经出血6天或更长时间的病史(44.4%对28.4%)、月经过多(44.8%对8.4%)以及中度或重度痛经(15.9%对7.5%)。两组中,70%的女性此前曾使用过Cu IUD。然而,LNG IUS接受者在先前使用Cu IUD期间出现的副作用更多(58.2%对28.8%)。她们还报告了更多导致先前Cu IUD停用的副作用(39.4%对10.1%)。然而,12个月生命表持续使用率分别为80.6(标准误1.9)%和83.4(标准误1.8)%,二者相似。Cu IUD使用者因出血和意外怀孕问题更常停用当前方法。在那些先前因激素副作用而停用激素避孕方法的女性中,两组的持续使用率没有差异。
LNG IUS可被无法使用Cu IUD或曾在口服避孕药时出现激素副作用的女性成功使用。