Department of Reproductive Medicine, University of California, San Diego, CA 92130, USA.
Contraception. 2011 Nov;84(5):525-32. doi: 10.1016/j.contraception.2011.02.010. Epub 2011 Mar 29.
In the female genital tract, vaginal colposcopy, endometrial mucosal integrity and inflammatory mediators are potential in vivo biomarkers of microbicide and contraceptive safety.
A randomized, blinded crossover trial of 18 subjects comparing effects of nonoxynol-9 vaginal gel (Gynol II; putative inflammatory gel), hydroxyethyl cellulose gel (HEC; putative inert gel) and no gel exposure on endometrial and vaginal epithelial integrity and endometrial and vaginal inflammatory markers [interleukin (IL) 1β, IL-6, IL-8, MCP-1, MIP-1α, MIP-1β, RANTES, tumor necrosis factor α, IL-1RA, IL-10, SLPI).
Gynol II was associated with more vaginal lesions. No endometrial disruptions were observed across conditions. In the vagina, RANTES (p=.055) and IL-6 (p=.04) were higher after HEC exposure than at baseline. In the endometrium, IL-1β (p=.003) and IL-8 (p=.025) were lower after Gynol II cycles than after no gel.
Gynol II and HEC may modulate inflammatory markers in the vagina and endometrium. How these changes relate to infection susceptibility warrants further study.
在女性生殖道中，阴道阴道镜检查、子宫内膜黏膜完整性和炎症介质是杀微生物剂和避孕安全性的潜在体内生物标志物。
一项随机、双盲交叉试验，比较了 18 名受试者在使用壬苯醇醚-9 阴道凝胶（Gynol II；疑似炎症凝胶）、羟乙基纤维素凝胶（HEC；疑似惰性凝胶）和不使用凝胶时对子宫内膜和阴道上皮完整性以及子宫内膜和阴道炎症标志物的影响[白细胞介素（IL）1β、IL-6、IL-8、MCP-1、MIP-1α、MIP-1β、RANTES、肿瘤坏死因子-α、IL-1RA、IL-10、SLPI]。
Gynol II 与更多的阴道损伤有关。在所有条件下，子宫内膜均未出现破坏。在阴道中，HEC 暴露后 RANTES（p=.055）和 IL-6（p=.04）高于基线。在子宫内膜中，Gynol II 周期后 IL-1β（p=.003）和 IL-8（p=.025）低于无凝胶。
Gynol II 和 HEC 可能会调节阴道和子宫内膜中的炎症标志物。这些变化与感染易感性的关系需要进一步研究。
