Harwood Bryna, Meyn Leslie A, Ballagh Susan A, Raymond Elizabeth G, Archer David F, Creinin Mitchell D
Department of Obstetrics and Gynecology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Am J Obstet Gynecol. 2008 Jan;198(1):32.e1-7. doi: 10.1016/j.ajog.2007.05.020.
This study was undertaken to compare the colposcopic appearance of the cervicovaginal epithelium with spermicide use vs condom use in a low-risk population.
This was an ancillary study of a trial comparing the efficacy of 5 nonoxynol-9 spermicides. A cohort of women who used condoms without spermicide served as a control group. Colposcopic examinations were performed during product use to identify genital lesions.
One hundred fifty-one participants had 1 or more follow-up examinations. At baseline, study groups differed only by the prevalence of baseline lesions. New lesions were identified at 49% of follow-up visits. Controlling for the presence of a baseline lesion, compared with condom use none of the spermicides were associated with an increase in new lesions (overall odds ratio, 0.8; 95% CI, 0.4-1.6; P = .5); and lesions characterized by epithelial disruption were less frequent with spermicide use (overall odds ratio, 0.3; 95% CI, 0.1-0.6; P < .001).
In a low-risk population, women who used nonoxynol-9 spermicides were less likely to have lesions with epithelial disruption, and equally likely to have any new lesion compared with condom use.
本研究旨在比较低风险人群中使用杀精剂与使用避孕套时宫颈阴道上皮的阴道镜表现。
这是一项比较5种壬苯醇醚-9杀精剂疗效的试验的辅助研究。一组使用不含杀精剂避孕套的女性作为对照组。在产品使用期间进行阴道镜检查以识别生殖器病变。
151名参与者进行了1次或更多次随访检查。在基线时，研究组仅在基线病变的患病率方面存在差异。在49%的随访中发现了新病变。在控制基线病变存在的情况下，与使用避孕套相比，没有一种杀精剂与新病变增加相关（总体优势比，0.8；95%可信区间，0.4 - 1.6；P = 0.5）；使用杀精剂时，以上皮破坏为特征的病变较少见（总体优势比，0.3；95%可信区间，0.1 - 0.6；P < 0.001）。
在低风险人群中，使用壬苯醇醚-9杀精剂的女性发生上皮破坏病变的可能性较小，与使用避孕套相比，出现任何新病变的可能性相同。
