Canciglia A, Mandolfino T, D'Alfonso M
University of Messina, Italy.
G Chir. 2011 Oct;32(10):434-7.
The purpose of this study was to assess the effect of Iloprost in the treatment of venous ulcers.
We recruited 52 patients with uncomplicated venous ulcers of the lower limbs. They were divided into two groups: the first (29 patients) was given Iloprost in saline solution for three weeks, while the second (23 patients) received saline solution only. The size and number of ulcers were determined at the start of the treatment and then every 15 days for six months.
Ulcer size diminished faster in the patients treated with Iloprost, with 100% healed within 120 days. In the placebo group, 82.60% had healed by the end of the 180-day observation period. This difference was statistically significant. Ulcer cicatrization was also faster in the treatment group (65.51% after 60 days, 86.20% after 90 days and 100% after 120 days), whereas in the placebo group, the ulcers had still not healed in 17.40% of patients by the study end.
Iloprost can significantly reduce healing time for venous leg ulcers without any specific complications.
本研究的目的是评估伊洛前列素治疗静脉溃疡的效果。
我们招募了52例下肢单纯性静脉溃疡患者。他们被分为两组：第一组（29例患者）给予伊洛前列素生理盐水溶液治疗三周，而第二组（23例患者）仅接受生理盐水溶液。在治疗开始时确定溃疡的大小和数量，然后在六个月内每15天确定一次。
接受伊洛前列素治疗的患者溃疡大小缩小更快，120天内100%愈合。在安慰剂组中，在180天观察期结束时82.60%的患者已愈合。这种差异具有统计学意义。治疗组溃疡愈合也更快（60天后为65.51%，90天后为86.20%，120天后为100%），而在安慰剂组中，到研究结束时仍有17.40%的患者溃疡未愈合。
伊洛前列素可显著缩短下肢静脉溃疡的愈合时间，且无任何特定并发症。
