三名弥漫性大B细胞淋巴瘤患者中存在的t(3;22)(q23;q11)易位。
Translocation t(3;22)(q23;q11) in three patients with diffuse large B cell lymphoma.
作者信息
Leroux D, Stul M, Sotto J J, Bastard C, Couderc P, Bensa J C, Monteil M, Cassiman J J, Jalbert P
机构信息
Department of Genetics, University Hospital, Grenoble, France.
出版信息
Leukemia. 1990 May;4(5):373-6.
In our series of 134 patients with a diagnosis of non-Hodgkin's lymphoma (NHL) and clonal chromosomal abnormalities, three were found to show an identical t(3;22)(q28;q11) translocation. All were old patients with isolated lymphadenomegaly and diffuse large noncleaved cell lymphoma. All expressed a B cell immunophenotype, and all entered a complete remission when treated with aggressive chemotherapy. This translocation could, therefore, delineate a particular subtype of diffuse large cell NHL.
在我们诊断为非霍奇金淋巴瘤（NHL）且有克隆性染色体异常的134例患者系列中，发现3例显示相同的t(3;22)(q28;q11)易位。所有患者均为老年患者，表现为孤立性淋巴结肿大和弥漫性大无裂细胞淋巴瘤。所有患者均表达B细胞免疫表型，在接受积极化疗后均进入完全缓解期。因此，这种易位可能界定了弥漫性大细胞NHL的一种特殊亚型。
Zotero 插件