Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Pigment Cell Melanoma Res. 2011 Dec;24(6):1107-11. doi: 10.1111/j.1755-148X.2011.00933.x.
In recent years, many groups have detected biomarkers of cellular senescence in a plethora of neoplastic lesions, in model systems, and humans. Indeed, we have come to realize that oncogene-induced senescence (OIS) acts as a potent barrier to oncogenic transformation, operating alongside cell death programs. We have begun to uncover some of its underlying principles, but many fundamental questions remain. In this perspective, some of the 'knowns' and 'unknowns' of OIS are discussed, with a focus on melanomagenesis.
近年来，许多研究小组在大量肿瘤病变、模型系统和人类中检测到细胞衰老的生物标志物。事实上，我们已经意识到，癌基因诱导的衰老（OIS）作为一种强大的致癌转化障碍，与细胞死亡程序一起发挥作用。我们已经开始揭示其一些潜在的原则，但仍有许多基本问题尚未解决。在这个观点中，讨论了 OIS 的一些“已知”和“未知”，重点是黑色素瘤发生。
