黑素细胞痣与癌基因诱导衰老的遗传和表观遗传调控
Melanocytic Nevi and the Genetic and Epigenetic Control of Oncogene-Induced Senescence.
作者信息
Huang Jennifer M, Chikeka Ijeuru, Hornyak Thomas J
机构信息
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene St., Baltimore, MD 21201, USA.
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene St., Baltimore, MD 21201, USA; Research & Development Service, VA Maryland Health Care System, Baltimore, MD, 21201, USA; Department of Dermatology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
出版信息
Dermatol Clin. 2017 Jan;35(1):85-93. doi: 10.1016/j.det.2016.08.001.
Abstract
Melanocytic nevi represent benign clonal proliferations of the melanocytes in the skin that usually remain stable in size and behavior or disappear during life. Infrequently, melanocytic nevi undergo malignant transformation to melanoma. Understanding molecular and cellular mechanisms underlying oncogene-induced senescence should help identify pathways underlying melanoma development, leading to the development of new strategies for melanoma prevention and early detection.
摘要
黑素细胞痣是皮肤中黑素细胞的良性克隆性增殖，其大小和行为通常保持稳定，或在生命过程中消失。黑素细胞痣很少发生恶性转化为黑色素瘤。了解癌基因诱导衰老的分子和细胞机制应有助于确定黑色素瘤发生发展的潜在途径，从而开发出预防和早期检测黑色素瘤的新策略。
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1
NF-kB2 induces senescence bypass in melanoma via a direct transcriptional activation of EZH2.
Oncogene. 2016 May;35(21):2813. doi: 10.1038/onc.2015.468.
2
NF-kB2 induces senescence bypass in melanoma via a direct transcriptional activation of EZH2.
Oncogene. 2016 May;35(21):2735-45. doi: 10.1038/onc.2015.331. Epub 2015 Sep 14.
3
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Pigment Cell Melanoma Res. 2015 Nov;28(6):661-72. doi: 10.1111/pcmr.12412.
4
Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma.
Cancer Discov. 2015 Apr;5(4):410-23. doi: 10.1158/2159-8290.CD-14-1473. Epub 2015 Feb 11.
5
Polycomb group proteins--epigenetic repressors with emerging roles in melanocytes and melanoma.
Pigment Cell Melanoma Res. 2015 May;28(3):330-9. doi: 10.1111/pcmr.12341. Epub 2015 Jan 7.
6
Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.
PLoS Genet. 2014 Sep 25;10(9):e1004642. doi: 10.1371/journal.pgen.1004642. eCollection 2014 Sep.
7
Melanocytic naevi with globular and reticular dermoscopic patterns display distinct BRAF V600E expression profiles and histopathological patterns.
Br J Dermatol. 2014 Nov;171(5):1060-5. doi: 10.1111/bjd.13260. Epub 2014 Oct 20.
8
EZH2: an emerging role in melanoma biology and strategies for targeted therapy.
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9
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Clin Cancer Res. 2013 Jan 15;19(2):393-403. doi: 10.1158/1078-0432.CCR-12-1626. Epub 2012 Nov 30.
10
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations.
N Engl J Med. 2012 Nov 1;367(18):1694-703. doi: 10.1056/NEJMoa1210093. Epub 2012 Sep 29.
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