De Bennetot M, Rabischong B, Aublet-Cuvelier B, Belard F, Fernandez H, Bouyer J, Mage G, Pouly J-L
Service de gynécologie-obstétrique et reproduction humaine, CHU de Clermont-Ferrand, CHU Estaing, 1, place Lucie-Aubrac, 63100 Clermont-Ferrand, France.
J Gynecol Obstet Biol Reprod (Paris). 2012 Feb;41(1):55-61. doi: 10.1016/j.jgyn.2011.09.002. Epub 2011 Oct 20.
Investigate and identify the risk factors influencing the recurrence of ectopic pregnancies.
The Auvergne ectopic pregnancy registry data were analyzed from 1992 to 2008. The appearance of a recurrence was studied among 1108 women from 18 to 44 years old, who attempted to conceive again.
One hundred and sixteen repeated ectopic pregnancies occurred (10.5 %) during the period under study. The rate of recurrence was significantly higher among women who had a history of voluntary termination of pregnancy (P=0.01). Conversely, fewer recurrences (P=0.01 and 0.0478) occurred among women having a history of infertility or previous live birth. The treatment for ectopic pregnancy, whether it is conservative or radical laparoscopic, or medical with methotrexate did not significantly influence the recurrence rate (P=0.86).
Reproductive history appears to involve the risk of repeated ectopic pregnancy and must be taken into account in their secondary prevention. As for the choice of treatment, the risk of recurrence does not seem to constitute a decisive argument.
调查并确定影响异位妊娠复发的风险因素。
分析了1992年至2008年奥弗涅异位妊娠登记处的数据。对1108名年龄在18至44岁之间、尝试再次受孕的女性的复发情况进行了研究。
在研究期间发生了116例重复性异位妊娠(10.5%)。有自愿终止妊娠史的女性复发率显著更高(P = 0.01)。相反,有不孕史或既往活产史的女性复发较少(P = 0.01和0.0478)。异位妊娠的治疗,无论是保守性还是根治性腹腔镜手术,还是使用甲氨蝶呤进行药物治疗,均未对复发率产生显著影响(P = 0.86)。
生殖史似乎与重复性异位妊娠的风险有关,在二级预防中必须予以考虑。至于治疗方法的选择,复发风险似乎并非决定性因素。