The Methodist Hospital, Houston, Texas 77030, USA.
Surv Ophthalmol. 2012 Jul-Aug;57(4):379-85. doi: 10.1016/j.survophthal.2011.05.002. Epub 2011 Oct 21.
A 60-year-old man presented with diplopia and neurocognitive deficits, which progressed rapidly over several months. Magnetic resonance imaging of the head revealed bilateral signal abnormalities and diffusion-weighted imaging restriction in bilateral basal ganglia, thalami, mesial temporal regions, and periaqueductal gray matter. Cerebrospinal fluid analysis was positive for 14-3-3 and tau proteins. The patient developed progressive neurocognitive decline followed by sleep disturbance and myoclonic jerking consistent with probable Creutzfeldt-Jakob disease.
一位 60 岁男性出现复视和神经认知功能缺损，这些症状在几个月内迅速进展。头部磁共振成像显示双侧基底节、丘脑、内侧颞叶和导水管周围灰质存在信号异常和弥散受限。脑脊液分析显示 14-3-3 和 tau 蛋白阳性。患者出现进行性神经认知功能下降，随后出现睡眠障碍和肌阵挛抽搐，符合可能的克雅氏病。
