血液源性供体肥大细胞前体细胞在成年小鼠中迁移到富含肥大细胞的脑区。
Blood-borne donor mast cell precursors migrate to mast cell-rich brain regions in the adult mouse.
机构信息
Department of Psychology, Columbia University, New York, NY 10027, United States.
出版信息
J Neuroimmunol. 2011 Dec 15;240-241:142-6. doi: 10.1016/j.jneuroim.2011.09.003. Epub 2011 Oct 22.
Abstract
Mast cells are hematopoietic immune cells located throughout the body, including within the brain. Reconstitution of mast cell deficient Kit(W-sh/W-sh) mice has proven valuable in determining peripheral mast cell function. Here we study the brain mast cell population using a novel method of blood transfusion for reconstitution. We show that blood transfusion results in mast cells of donor origin in the WT mouse, including in the brain where they are restricted to regions bearing host mast cells. In contrast, in Kit(W-sh/W-sh) mice, transfusion results in mast cells in the pinna of the ear, but not the brain.
摘要
肥大细胞是位于全身的造血免疫细胞，包括大脑内。重建肥大细胞缺陷型 Kit(W-sh/W-sh) 小鼠已被证明在确定外周肥大细胞功能方面具有重要价值。在这里，我们使用一种新的输血重建方法来研究大脑肥大细胞群体。我们表明，输血会导致供体来源的肥大细胞出现在 WT 小鼠中，包括在大脑中，这些细胞局限于具有宿主肥大细胞的区域。相比之下，在 Kit(W-sh/W-sh) 小鼠中，输血会导致耳部耳甲的肥大细胞，但不会导致大脑中的肥大细胞。
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